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Skip to Search Results- 1Elezzabi, Muhammad A.
- 1Ellestad, Kristofor K
- 1Havele, Calliopi.
- 1Hu, Qian
- 1Leung, Wing Sze W
- 1Sadelain, Michel W. J.
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Fall 2010
This dissertation addresses different kinds of Mandarin multi-verb constructions (MVCs), seeking to solve a long-standing problem in Chinese linguistics: namely, how to account for a plethora of constructions, including a subset called serial verb constructions. In most previous studies, only a...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Spring 2011
This study compares the role of cognitive processes in children diagnosed with learning disabilities (LD) through the traditional aptitude-achievement discrepancy model with students diagnosed on the basis of their low achievement alone. Historically, in North American settings, LD has been...
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Mechanisms underlying lymphopenia-driven autoimmunity in the setting of co-inhibitory molecule deficiency
DownloadFall 2016
T lymphocytes (T cells) are powerful directors and effectors of immunity. The system of pseudo-random rearrangements of the T cell receptor (TCR) loci that underlie their ability to recognize a vast universe of molecular patterns is at once useful and dangerous, because many T cells develop TCR...
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Mental Health Co-morbidity in Children and Adolescents with Fetal Alcohol Spectrum Disorder
DownloadSpring 2016
Children and adolescents with Fetal Alcohol Spectrum Disorder (FASD) present with a range of physical, mental, behavioral, and cognitive challenges which can result in poor long-term outcomes. Mental health issues affect over 90% of individuals with FASD and is the most common and pressing...
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Fall 2011
The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...
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Short- and Long-Term Impacts of A Working Memory Intervention for Children with Prenatal Alcohol Exposure
DownloadSpring 2018
This dissertation consists of two studies designed to: (1) determine the neurobehavioural profile reflecting the strengths and limitations of children with Parental Alcohol Exposure (PAE) and (2) evaluate the short- and long-term impacts of a 25-session Cogmed© intervention on improving working...