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- 9Arachidonic acid
- 3Calcium--Physiological effect
- 3Cardiac hypertrophy
- 3Docosahexaenoic acid
- 2Breast milk
- 2Cytochrome P450
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Author / Creator / Contributor
- 1Aghazadeh Habashi, Ali
- 1Al Lawati, Hanan M
- 1Alsaad,Abdulaziz M
- 1Beaulieu, Michael J.
- 1Coleman, Robert J.
- 1El-Sherbeni, Ahmed Abd El-Hakeem
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- 6Faculty of Pharmacy and Pharmaceutical Sciences
- 3Department of Agricultural, Food, and Nutritional Science
- 1Centre for Neuroscience
- 1Department of Foods and Nutrition
- 1Department of Oncology
- 1Department of Pharmacology
Supervisors
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Dr. Ayman El-Kadi
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 1Field, Catherine (Agricultural, Food and Nutritional Science)
- 1Field, Catherine J. (Agriculture, Food and Nutritional Science)
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Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
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The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell line
DownloadFall 2015
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
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