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Skip to Search Results- 2Veldhoen, Richard
- 1Abbasi Dezfouli, Meysam
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Airo, Adriana M
- 1Allen, D. M.
- 50Graduate and Postdoctoral Studies (GPS), Faculty of
- 50Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 1Pharmacy and Pharmaceutical Sciences, Faculty of
- 1Pharmacy and Pharmaceutical Sciences, Faculty of/Journal Articles (Pharmacy and Pharmaceutical Sciences)
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From the basic understanding of N-myristoylation during apoptosis to a potential personalized medical treatment of B cell lymphomas
DownloadFall 2013
Myristoylation is a type of fatty acylation that involves the irreversible attachment of myristate (C14) to an amino-terminal glycine of a protein via an amide bond by N-myristoyltransferase (NMT). The two human N-myristoyltransferases (NMT1 and NMT2) typically play a pro-survival role in cells...
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Fall 2012
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during...
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...
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Fall 2013
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
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Spring 2013
AKT inhibits apoptosis and stimulates cap-dependent translation by phosphorylating key downstream cellular proteins. Many viruses therefore activate the PI3-kinase-AKT signaling pathway to promote cell survival and viral protein synthesis. HSV-1 activates AKT during lytic infection and the...
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Fall 2021
Caspases are a family of enzymes that regulate biological processes, such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the mitochondria, which leads to the activation of...
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Insights into the role of CTP:phosphocholine cytidylyltransferase-alpha in hepatic lipid metabolism and cellular integrity
DownloadFall 2011
Lower levels of hepatic phosphatidylcholine (PC) are suggested to play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Mice lacking hepatic CTP:phosphocholine cytidylyltransferase-α (LCTα-/-), the regulatory enzyme in the CDP-choline pathway for PC biosynthesis, were fed a...
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Interactions between Amyloid Precursor Protein and Prion Protein Impact Cell Adhesion and Apoptosis in the Developing Zebrafish
DownloadFall 2011
We report here that knockdown of either amyloid precursor protein (APP) or prion protein (PrP) in the zebrafish produces an overt dose-dependent phenotype characterized by systemic morphological defects and CNS cell death. We report findings that the zebrafish PrP-1 gene genetically interacts...
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Fall 2014
The growth and development of an organ is a multi-step process. It involves initial specification of the progenitor cells to become a particular cell type, proliferation of those cells for organ growth, and organization of the cells into a final functional tissue. The growth and development of...
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Spring 2013
The activation of caspases is an important step not only in apoptosis induction, but in cellular processes such as proliferation, differentiation, and the immune response. Here, we show that the AP-1 family transcription factor JunB is cleaved and dephosphorylated in a caspase-dependent manner in...