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Skip to Search Results- 1Aghazadeh Habashi, Ali
- 1Al Lawati, Hanan M
- 1Alsaad,Abdulaziz M
- 1Althurwi, Hassan N
- 1Asghar, Muhammad Waheed
- 1Chaudhary, Ketul R
- 4El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Jamali, Fakhreddin (Pharmaceutical Sciences)
- 1Ayman, El-Kadi (Pharmacy and Pharmaceutical Sciences)
- 1Barakat, Khaled (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Dr. Ayman El-Kadi
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Fall 2017
The voltage-gated KCNQ1/KCNE1 potassium ion channel plays a key role in maintaining the heart rhythm. An active channel generates the slow delayed rectifier (IKs) current in the heart. Both loss-of-function and gain-of-function mutations in KCNQ1 or KCNE1 are linked to many heart-related...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Effects of Inflammation and Non-Steroidal Anti-Inflammatory Drugs on Renin-Angiotensin System and Cytochrome P450 Metabolites of Arachidonic Acid
DownloadSpring 2016
Patients suffering from inflammatory disorders are at higher risk of cardiovascular (CV) morbidity and mortality compared to general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation associated with inflammatory disorders such as rheumatoid...
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Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis
DownloadSpring 2015
Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union, while it is considered as a nutraceutical in North America. The effectiveness of GlcN for ameliorating the...
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MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHY
DownloadSpring 2017
El-Sherbeni, Ahmed Abd El-Hakeem
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET
DownloadSpring 2017
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
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Fall 2012
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...
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Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
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THE ROLE OF CYTOCHROME P450 AND THEIR ASSOCIATED ARACHIDONIC ACID METABOLITES IN THE INITIATION AND PROGRESSION OF CARDIAC HYPERTROPHY
DownloadSpring 2016
Heart failure (HF) is the leading cause of mortality and disability in adults worldwide. Cardiac hypertrophy is an independent risk factor and one of the major hallmarks of HF. Research in cardiac hypertrophy is considered as a research into the early events in the development of HF. The...
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The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
DownloadFall 2021
Cardiac hypertrophy is a complex condition which is characterized by increased mass of the heart muscle. If untreated, cardiac hypertrophy can ultimately lead to heart failure (HF), arrhythmia and sudden death. Accumulating evidence suggest that pathological cardiac hypertrophy is strongly...