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Cognitive Resilience to Frailty and Mobility Adversities in Aging: Data-Driven Approach to Classification and Prediction by Risk Factors for Alzheimer’s Disease
DownloadSpring 2021
Objective: The overall aim of the current dissertation was to examine how and why some older adults maintain their cognitive performance for long periods of time, despite the presence of physical adversity factors known to be associated with the deterioration of cognitive function. We examined...
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Evaluation of Frailty Assessment Tools and their Measurement Properties in Chronic Kidney Disease
DownloadSpring 2022
Background: Frailty is three to seven times more common in people with chronic kidney disease (CKD) than in those with normal kidney function. Although frailty and its impact in CKD is well-recognized, the measurement properties of the tools used to assess this syndrome are not known. The aim of...
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Exploring the Association Between Frailty and Adverse Clinical Outcomes in Inflammatory Bowel Disease
DownloadFall 2022
Background and Rationale: Chronological age does not always accurately reflect “biological age”, or the extent of physiological reserve an individual possesses to endure stressors. The concept of physiological reserve is best represented by frailty; a multifaceted syndrome or state that...
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Giardiasis in children attending daycare centers in Guatemala and the therapeutic potential of ganglioside
DownloadSpring 2011
Intestinal enteropathy is a prevalent yet neglected aspect of child malnutrition involving chronic exposure to intestinal pathogens such as Giardia intestinalis. Gangliosides have therapeutic potential for the treatment of giardiasis and intestinal enteropathy. The objectives of the thesis were...
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Vitamin D Status and Health-care Outcomes in an Ambulatory Population of Patients with Diabetes and Chronic Kidney disease: A Five-year Follow-up.
DownloadSpring 2018
Vitamin D (VitD) deficiency is a prevalent condition in Canada, especially in northern latitudes where sunlight exposure is limited. Elderly patients especially those with chronic conditions such as Diabetes Mellitus (DM) and Chronic Kidney Disease (CKD) have a higher risk of developing vitD...