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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2013
The placenta is an essential transitory fetal organ responsible for the key processes of nutrient, oxygen, and waste transfer between the mother and the fetus throughout gestation. Placental size is, importantly, known to correlate to fetal weight, and the malfunction and malformation of the...
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Molecular imaging of cyclooxygenase-2 (COX-2) and autotaxin (ATX) in cancer using positron emission tomography (PET)
DownloadFall 2020
Positron emission tomography (PET) relies on the use of β+-emitting radionuclide-bearing molecules congregating and decaying at a specific site of interest. Use of these molecules, called radiotracers, which target common tumor characteristics has become a pillar in the diagnosis of cancer and...
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2019-12-10
Serpe, Michael J., Schirrmacher, Ralf
NFRF Exploration awarded in 2020: Positron Emission Tomography (PET) is among the most sophisticated in vivo imaging modalities using radioactive isotopes that decay by positron emission. PET is non-invasive, painless, and hence patient friendly; provides full-depth images of the human body...
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Novel Insights into the Role of O6-Methylguanine-DNA Methyltransferase in Glioblastoma Angiogenesis, Invasion, and Proliferation
DownloadFall 2012
Glioblastoma multiforme (GBM) is characterized by aberrant angiogenesis, rapid proliferation, and widespread invasion through the brain parenchyma. Thus, the prognosis for these tumors remains extremely poor despite aggressive multimodal treatment including chemotherapy with the alkylating agent...
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Fall 2019
Glioblastoma (GBM), classified as WHO grade IV astrocytoma, is the most common and lethal adult primary brain tumour. Despite recent advances in treatment, GBM prognosis remains largely unchanged with most patients succumbing to the disease within ~15 months of diagnosis. This dismal outcome can...
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Oncology Patients’ Experiences of Using Electronic Patient Portals and Other Online Tools to Support Care and Treatment
DownloadSpring 2022
With the current proliferation of clinical information technologies in Canada, patient portals and other online tools are becoming increasingly adopted in healthcare. Many people use the Internet for health-related purposes to connect with peer support groups and read about their medical...
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Fall 2016
Background: Posttraumatic growth (i.e., positive psychological growth following a traumatic event) is a desired outcome of a cancer diagnosis, however, there is limited research examining interventions to foster experiences of growth. The benefits of physical activity for cancer survivors have...
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Physical Therapy Interventions for Children and Adolescents with Cancer: Collating the Evidence from Research and Clinical Practice
DownloadSpring 2018
Purpose: Children and adolescents with cancer who undergo cancer treatment are at high risk of developing serious late and long-term physical effects, many of which may be amenable to physical therapy (PT). Little is known about the benefits of PT or the services currently provided to address...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...