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Skip to Search Results- 1Abu Alrub, Osama Y
- 1Aderibigbe, Ayodeji O.
- 1Agellon, Luis B.
- 1Al-Momany, Abass M T
- 1Berke, Sheldon S
- 1Chahal, Manik
- 27Graduate and Postdoctoral Studies (GPS), Faculty of
- 27Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
- 1Nursing, Faculty of
- 1Nursing, Faculty of/Chronicity
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Spring 2015
Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...
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Fall 2014
An organoarsenic compound, 3-nitro-4-hydroxyphenyl arsenic acid (also known as Roxarsone), has been used as a feed additive. Roxarsone was approved by the Food and Drug Administration (FDA) to control diseases in poultry, and to improve weight gain, feed efficiency, and meat pigmentation....
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Spring 2015
The kidneys regulate total body fluid volume, acid-base status, and electrolyte composition through the filtration of large amounts of plasma by glomerular capillaries, followed by selective reabsorption of solutes and water by renal tubules. To sustain filtration, the hydraulic pressure within...
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COUP-TF1 antagonizes Nkx25-mediated activation of the calreticulin gene during cardiac development
Download2001-01-01
Guo, Lei, Lynch, Jeffrey, Nakamur, Kimitoshi, Fliegel, Larry, Kasahara, Hideko, Izumo, Seigo, Komuro, Issei, Agellon, Luis B., Michalak, Marek
Calreticulin, a Ca2+ binding chaperone of the endoplasmic reticulum, is also highly expressed in the embryonic heart, and knockout of the calreticulin gene is lethal during embryogenesis because of impaired cardiac development. The protein is down-regulated after birth, and elevated expression of...
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Divine Corporeality: Remembering Yhwh's Different Body Parts in Late Persian/Early Hellenistic Yehud/Judah
DownloadSpring 2017
In an effort to contribute to the rich and ongoing conversation on divine anthropomorphism(s), this work examines references to Yhwh’s various body parts in Late Persian/Early Hellenistic period texts of (what is now known in scholarly circles as) the Hebrew Bible from the perspective of social...
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Fall 2017
Epidermal Growth Factor-like domain 7 (EGFL7) is a secreted angiogenic factor that is almost exclusively expressed by endothelial cells. High EGFL7 expression occurs during physiological angiogenesis, under pathological conditions, and in solid tumor angiogenesis. Evidence suggests that EGFL7...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...