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Skip to Search Results- 20Older adults
- 18Alzheimer's disease
- 13Meta-analysis
- 4Systematic reviews
- 3Amyloid precursor protein
- 2Amyloid beta
- 1Afifi, Mona
- 1Asaad, Ghada A
- 1Barrington, Catherine
- 1Chen, Serena K
- 1Cochrane, Karen
- 1Compton, Roslyn M
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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The Effectiveness of Cognitive Behavioural Therapy for Secondary Prevention of Coronary Heart Disease: A Meta-Analysis
DownloadFall 2015
The effectiveness of secondary prevention (SP) for coronary heart disease (CHD) is well established. The poor integration of evidence into clinical practice remains problematic, in part due to the poor description of trials evaluating these programs. As a result, knowledge users remain unclear...
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The Effects of Reading Interventions on the Word-Reading Performance of English Language Learners: A Meta-Analysis
DownloadFall 2017
Despite a large body of research on the effectiveness of reading interventions for monolingual English speakers, research on reading interventions for English language learners (ELLs) is still relatively scarce. Because the number of ELLs in schools is growing rapidly and these students often...
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The impact of bias on the magnitude of treatment effect estimates in oral health randomized trials
DownloadFall 2016
Background: There is emerging evidence that randomized trials are subject to biases. Flaws in the design of such trials can result in over- or underestimation of the treatment effect size. Aim: To examine the empirical evidence for bias, to quantify the extent of bias associated with methodology,...
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Thermal response of amyloidogenic elements in cultured N2a cells: potential relevance to Alzheimer’s disease pathology
DownloadFall 2020
Alzheimer’s disease (AD) weighs a large burden on health care systems, families and caregiving networks around the world. It is the most common dementia afflicting elderly individuals, and causes many debilitating symptoms, including memory loss, mood swings and confusion which progress in...
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Understanding the Experiences of the Community-Dwelling Older Adults of the FallProofTM Program
DownloadFall 2019
Background: One in three community-dwelling older adults aged 65 years or older experience at least one fall per year, leading to fall-related injuries, loss of independence, and, in some instances, death. Effective interventional strategies exist to prevent falls and their negative consequences...
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Spring 2012
This study examined the usability of medication adherence technologies (MATs) to improve medication adherence among older adults. A MATs survey and a product trial were used to understand the perspectives of health care providers and older adults. The survey was distributed to health care...
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Use of autobiographical memory cues as cognitive support for episodic memory: Comparison of individuals with mild-stage Alzheimer's disease and healthy older adults
DownloadFall 2009
The purpose of the study was to examine the effectiveness of autobiographical memories to support the improvement of episodic memory (i.e., word recall) in patients with mild- stage Alzheimer’s Disease (AD) and healthy older adults. Participants included 20 healthy young-old adults (M Age =...
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Using Machine Learning to Identify Common Engagement-Related Behaviours Demonstrated by Older Adults with Dementia While Playing Mobile Games
DownloadFall 2022
Background: Dementia causes impairment of a person’s memory, cognitive abilities, and behaviour, making it difficult for a person to complete daily tasks. Dementia affects the behavioural, psychological, and social dimensions of older adults living with the disease. Older adults living with...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...