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- 18Alzheimer's disease
- 4Cognitive impairment
- 3Amyloid precursor protein
- 2Amyloid beta
- 2Autophagy
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Rural Older Adult Physical Activity Participation and Promotion in Cape Breton, Nova Scotia
DownloadFall 2012
Given the relatively high rates of physical inactivity among older adults in Nova Scotia (NS) (Statistics Canada, 2011), the purpose of this study was two-fold: 1. To examine the physical activity (PA) beliefs, perceptions and experiences of rural older adults in rural Cape Breton, NS and 2. To...
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Fall 2009
Social support is important for health and well-being and has been associated with reduced isolation in rural communities. Support from family and friends may become increasingly important as one ages, and may enable some seniors to remain living in their communities. The purpose of this project...
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Speech and Language Disorders in Older Canadians: Epidemiologic Primary Care-Based Research Using the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) Database
DownloadFall 2016
Objectives: The objective of this study is to examine the epidemiology and clinical management in primary care of speech and language disorders in older adults (fifty-five and older) and to assess the utility and feasibility of EMR data to answer such research questions. This study is comprised...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Thermal response of amyloidogenic elements in cultured N2a cells: potential relevance to Alzheimer’s disease pathology
DownloadFall 2020
Alzheimer’s disease (AD) weighs a large burden on health care systems, families and caregiving networks around the world. It is the most common dementia afflicting elderly individuals, and causes many debilitating symptoms, including memory loss, mood swings and confusion which progress in...
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Understanding the Experiences of the Community-Dwelling Older Adults of the FallProofTM Program
DownloadFall 2019
Background: One in three community-dwelling older adults aged 65 years or older experience at least one fall per year, leading to fall-related injuries, loss of independence, and, in some instances, death. Effective interventional strategies exist to prevent falls and their negative consequences...
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Spring 2012
This study examined the usability of medication adherence technologies (MATs) to improve medication adherence among older adults. A MATs survey and a product trial were used to understand the perspectives of health care providers and older adults. The survey was distributed to health care...
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Use of autobiographical memory cues as cognitive support for episodic memory: Comparison of individuals with mild-stage Alzheimer's disease and healthy older adults
DownloadFall 2009
The purpose of the study was to examine the effectiveness of autobiographical memories to support the improvement of episodic memory (i.e., word recall) in patients with mild- stage Alzheimer’s Disease (AD) and healthy older adults. Participants included 20 healthy young-old adults (M Age =...
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Using Machine Learning to Identify Common Engagement-Related Behaviours Demonstrated by Older Adults with Dementia While Playing Mobile Games
DownloadFall 2022
Background: Dementia causes impairment of a person’s memory, cognitive abilities, and behaviour, making it difficult for a person to complete daily tasks. Dementia affects the behavioural, psychological, and social dimensions of older adults living with the disease. Older adults living with...