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Skip to Search Results- 1Athanassakis-Vassiliadis, Irene
- 1Azad, Abul
- 1Badr, Dina EFA
- 1Berke, Sheldon S
- 1Chahal, Manik
- 1Chen, Xueyi
- 6Department of Medicine
- 3Department of Oncology
- 2Department of Agricultural, Food, and Nutritional Science
- 2Department of Medical Sciences
- 2Department of Physiology
- 2Medicine
- 2Halloran, Philip (Medicine)
- 1Abdulkarim, Bassam (Oncology)
- 1Allan Murray (Medicine)
- 1Ambrose, Divakar (Department of Agricultural, Food and Nutritional Science)
- 1Bell, Rhonda (Department of Agricultural, Food, and Nutritional Science)
- 1Davidge, Sandra T (Department of Physiology, Department of Obstetrics and Gynaecology)
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Bilateral Uterine Artery Ligation in Rats cultivates Long Term Neurological Deficits reminiscent of Human Cerebral Palsy: A model for Therapeutic Intervention.
DownloadFall 2015
Introduction Cerebral Palsy (CP) is a ubiquitous term used to describe a group of permanent, non-progressive disorders of movement, posture, and behaviour. Despite countless advances in neonatal medicine, the incidence of CP has remained constant in term infants over the last three decades. More...
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Cardiovascular Effects of Aerobic Exercise Training in Hypoxic-induced Intrauterine Growth Restriction
DownloadFall 2017
Fetal hypoxia is one of the most common consequences of complicated pregnancies worldwide. It has been demonstrated that prenatal hypoxia leads to intrauterine growth restriction (IUGR). Being born growth restricted is associated with a decrease in cardiomyocyte proliferation, an increased...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Distinct Roles of Class 1 PI3K Isoforms in the Regulation of Beta Cell Exocytosis and Insulin Secretion
DownloadFall 2014
Type 2 diabetes (T2D) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic beta cell. The incidence of T2D is rising worldwide at an alarming rate. An increase in population growth, increased prevalence of obesity, and an aging population...
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Fall 2017
Epidermal Growth Factor-like domain 7 (EGFL7) is a secreted angiogenic factor that is almost exclusively expressed by endothelial cells. High EGFL7 expression occurs during physiological angiogenesis, under pathological conditions, and in solid tumor angiogenesis. Evidence suggests that EGFL7...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Exploiting the Enhanced Permeability and Retention Effect for the Targeting of Tumors with 18F-SiFA Polymer Nanoparticles
DownloadFall 2017
Over the last several decades great progress has been made in cancer diagnosis and detection. One foundation of this progress has been improved imaging technologies. Among the most promising imaging technologies for cancer detection is Positron Emission Tomography (PET). PET imaging allows for...
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Spring 2013
AKT inhibits apoptosis and stimulates cap-dependent translation by phosphorylating key downstream cellular proteins. Many viruses therefore activate the PI3-kinase-AKT signaling pathway to promote cell survival and viral protein synthesis. HSV-1 activates AKT during lytic infection and the...
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High fructose intake during pregnancy adversely affects insulin resistance, lipid profiles, and affects placental gene expression of nutrient transporters and angiogenesis in rat dams and their pregnant offspring
DownloadSpring 2017
Fructose intake has increased over the past several decades due to high consumption of sugary foods and drinks. In non-pregnant humans and animals, high fructose intake results in hyperlipidemia, insulin resistance and weight gain, although its effects on metabolic adaptations to pregnancy and on...