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Skip to Search Results- 45Graduate and Postdoctoral Studies (GPS), Faculty of
- 45Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 18Oil Sands Research and Information Network (OSRIN)
- 9Oil Sands Research and Information Network (OSRIN)/AOSERP Reports
- 7Biological Sciences, Department of
- 7Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Proposed design for a program of toxicological research for the Alberta Oil Sands Environmental Research Program
Download1979
Biggs, D. F., Croft, B., Loman, A. A., Jantzie, T., Coutts, R. T.
A proposed design, and supporting information, for an integrated program of toxicological research for the Alberta Oil Sands Environmental Research Program is presented. The first major section of the report (Section 2) contains background information pertinent to the development of a research...
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Regulation of Pancreatic β-cell Life and Death in the Context of Type 2 Diabetes: Study of the Potential Implication of the Orphan Nuclear Receptor NR4A3/Nor1 and the NZF Transcription Factor ST18.
DownloadFall 2017
Background: The insulin-secreting pancreatic beta-cell plays a central role in the maintenance of glucose homeostasis and in the pathogenesis of both type 1 and type 2 diabetes mellitus. In both cases, production of pro-inflammatory cytokines causes beta-cell apoptosis, which results in the...
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Retrograde signaling mechanisms of nerve growth factor regulating the survival and apoptosis of sympathetic neurons
DownloadFall 2009
The survival of several neuron populations during development, including sympathetic neurons, is strictly regulated by neurotrophins such as nerve growth factor (NGF) released from innervation targets. NGF activates its receptor, TrkA, at axon terminals, to generate signals that are transmitted...
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2014-09-24
Belosevic, M., Singh, A., Gamal El-Din, M., Li, C., McPhedran, K., Chelme-Ayala, P., Klamerth, N.
Large volumes of oil sands process-affected water (OSPW) are produced by the surface-mining oil sands industry in Alberta. The industry is following a no-release practice for OSPW due to its potential environmental toxicity. Both laboratory and field studies have demonstrated that OSPW is toxic...
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Targeting Phosphatidylserine for Positron Emission Tomography Imaging of Cell Death: Annexin V versus Phosphatidylserine-Binding Peptides
DownloadSpring 2016
There is currently no clinically approved, widely used molecular imaging agent for in vivo detection of cell death. Such an agent would be highly useful for early assessment of treatment efficacy in cancer patients, as well as for monitoring many other diseases in which cell death plays an...
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1979
Giles, M. A., Lawrence, S. G., Klaverkamp, J. F.
In order to conduct oil sands mining operations in the surface mining region of the Athabasca oil sands deposits, most regions require depressurization of the basal sandstone formations. The groundwater produced by depressurization operations is of poor enough quality to be toxic to fish. The...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
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The evaluation of toxic effects induced by exposure of mammals to oil sands process-affected water and its organic fraction
DownloadSpring 2018
Oil sands process-affected water (OSPW) produced by the surface-mining oil sands industry in Alberta, has been shown to be toxic to a variety of organisms. Much of this toxicity has been attributed to the dissolved organic compounds, primarily naphthenic acids (NAs). Under a no-release practice,...
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1977
The impact of saline waters upon freshwater biota, having special reference to the AOSERP study area, is reviewed. Available information on water quality in the AOSERP study area indicates that: the natural regional surface water quality does not appear to have any toxic effects, and chloride...