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Skip to Search Results- 52Mass-spectrometry
- 24Lipids
- 9Metabolomics
- 8Metabolic Syndrome
- 5Electrospray ionization
- 4Carbohydrates
- 8Klassen, John S.
- 4Kitova, Elena N.
- 4Liu, Lan
- 4Lowary, Todd L.
- 4Proctor, Spencer D.
- 3Borthwick, Faye
- 56Graduate and Postdoctoral Studies (GPS), Faculty of
- 56Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 11Agricultural, Food and Nutritional Science, Department of
- 11Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 9Chemistry, Department of
- 9Chemistry, Department of/Journal Articles (Chemistry)
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Fall 2016
Lipidomics is a research field that attempts to achieve the comprehensive analysis of the entire lipidome in a biological system. The emergence and rapid expansion of lipidomic studies is driven by the great advances in chromatographic separation and mass spectrometry. For this dissertation, I...
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Spring 2013
Huntington disease (HD) is a neurodegenerative disorder characterized by motor and cognitive symptoms. In HD patients, the protein huntingtin contains an abnormal expansion of a polyglutamine tract, which leads to the selective dysfunction and death of striatal and cortical neurons. Among other...
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Spring 2015
Protein silencing by small interfering RNA (siRNA) is a promising treatment strategy for cancer as over-expression of proteins is largely responsible for cancer cells’ infinite proliferation, evasion of cell death and multi-drug resistance. However, siRNAs require a carrier as their biological...
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Fall 2019
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Abnormal levels of circulating lipids (dyslipidemia) is a well-known risk factor for CVD. Traditionally, fasting lipids, inclusive of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), have...
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2009
Wishart, D.S., Psychogios, N., Young, N., Xia, J.
Metabolomics is a newly emerging field of ‘omics’ research that is concerned with characterizing large numbers of metabolites using NMR, chromatography and mass spectrometry. It is frequently used in biomarker identification and the metabolic profiling of cells, tissues or organisms. The data...
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Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells
Download2015
Chakrabarti, Subhadeep, Wu, Jianping
Milk derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) have shown promise as anti-hypertensive agents due to their inhibitory effects on angiotensin converting enzyme (ACE). Due to the key inter-related roles of hypertension, chronic inflammation and insulin resistance in the...
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Non-fasting remnant cholesterol as a predictor for cardiovascular disease risk in Canadians with and without diabetes mellitus in the Alberta’s Tomorrow Project
DownloadFall 2022
Cardiovascular disease (CVD) is a leading cause of death in Canada, and its risk of development is 3 times greater in those with diabetes mellitus (DM). Fasting low-density lipoprotein cholesterol (LDL-C) is the traditional lipid biomarker used in CVD risk assessment. While lowering LDL-C does...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...