Search
Skip to Search Results- 2Berry, Tanya R
- 2Veldhoen, Richard
- 1Aburahess, Salah
- 1Akuamoah Boateng, Maxwell
- 1Alberta Centre for Active Living
- 1Alqahtani,Hind M
- 38Graduate and Postdoctoral Studies (GPS), Faculty of
- 38Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 3Kinesiology, Sport, and Recreation, Faculty of
- 2Kinesiology, Sport, and Recreation, Faculty of/Research Data and Materials (Kinesiology, Sport, and Recreation)
- 1St. Stephen's College
- 1St. Stephen's College/Department of Psychotherapy and Spirituality (St. Stephen's College)
-
A Combined Computational and Experimental Investigation of Polynucleotide Binding Polymers for Therapeutic Applications
DownloadFall 2017
Polynucleotide binding polymers have a wide range of therapeutic applications including delivery systems for therapeutic polynucleotides, and antithrombotic drugs for extracellular nucleic acid-mediated thrombogenic events. This dissertation explores polynucleotide binding polymers in these two...
-
Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
-
Association mapping of genes using whole genome polymorphism arrays: Identification of markers of breast cancer susceptibility in Alberta women
DownloadFall 2010
Chakravarthy Sridharan, Malinee
Breast cancer is a heterogeneous, polygenic disease and is influenced by genetic, environmental and life-style factors. Many single nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified in genome-wide association studies (GWASs) by several research groups for...
-
Spring 2015
Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in plasma. Lysophosphatidate mediates many physiological and pathological processes by signaling through six G-protein-coupled receptors to promote...
-
Binding, internalization, and transgene expression of an adenoviral vector retargeted to HER3/4
DownloadFall 2013
Adenoviruses (Ads) have been well studied for use in cancer gene therapy. However, low levels of the primary receptor, coxsackie-adenovirus receptor (CAR), in tumor cells has been shown to be a factor in low transgene expression. To increase Ad infection of breast cancer cells we constructed a...
-
Spring 2012
This dissertation explores breast cancer experiences by predominately contemporary American women that are creative interventions into, and re-visions of, experiences in medical and therapeutic environs as well as culturally produced post-surgical bodies. During diagnoses, surgeries and...
-
DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cells
DownloadSpring 2016
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...
-
Developing an M3 Antagonist for Molecular Imaging of Muscarinic Acetylcholine Receptors in Breast Cancer
DownloadFall 2021
The lack of the three targeted receptors, estrogen, progesterone, and the human epidermal growth factor receptor 2, causes difficulty in treating triple negative type cancers. Most often, patients with this type of malignancy have a low chance of survival. The focus of this work will be on...