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Skip to Search Results- 1Ahmed, Kazi Tanveer
- 1Aroonassala Patten, Shunmoogum
- 1Attia, Karen
- 1Barlott, Timothy
- 1Brewster, Daniel L
- 1Cheng, Caroline ST
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Exploring the cultural construction of children's play in Thailand: an action research study with the Foundation for Child Development
DownloadFall 2011
Children’s play has emerged as a global discourse (Fleer, 2009). Studies from diverse theoretical traditions have examined the role of play in child development; however, the dominant discourse of play has largely privileged Western European-heritage cultural practices, and as a result childhood...
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Functional Characterization of Homeodomain Transcription Factors and Retinoic Acid Signaling in Hematopoiesis
DownloadSpring 2015
Improper regulation of hematopoiesis generates a spectrum of defects that range from anemia and embryonic lethality to leukemia. Identifying the molecular pathways that regulate hematopoiesis is therefore a major goal of both basic and clinical biology. Vertebrate hematopoiesis occurs in two...
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Spring 2024
To maintain an effective barrier, intestinal epithelial progenitor cells must divide at a rate that matches the loss of dead and dying cells. Epithelial damage during most enteric infection accelerates cell proliferation and tissue repair via multiple stress responses. However, infection with the...
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Identification and Molecular Characterization of Zebrafish (Danio rerio) Leukocyte Immune-Type Receptors (DrLITRs)
DownloadSpring 2020
In response to foreign invaders, innate immune cells use cell surface-expressed receptors to trigger intracellular signalling cascades that control various effector responses designed to destroy microbes. These specialized receptors are known as immunoregulatory receptors and structurally they...
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Improving chemotherapeutic regimens by mitigating hearing loss as a limiting side-effect and examining transition metal ions as a ligand for zebrafish Tlr4
DownloadFall 2023
Cancer is often a debilitating disease associated with the uncontrolled growth of cells within an organism. We have made significant strides over the past few decades in treating many cancers, unfortunately, many of these treatments have unfavourable side effects. Cisplatin is a revolutionary...
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Interactions between Amyloid Precursor Protein and Prion Protein Impact Cell Adhesion and Apoptosis in the Developing Zebrafish
DownloadFall 2011
We report here that knockdown of either amyloid precursor protein (APP) or prion protein (PrP) in the zebrafish produces an overt dose-dependent phenotype characterized by systemic morphological defects and CNS cell death. We report findings that the zebrafish PrP-1 gene genetically interacts...
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Fall 2014
The growth and development of an organ is a multi-step process. It involves initial specification of the progenitor cells to become a particular cell type, proliferation of those cells for organ growth, and organization of the cells into a final functional tissue. The growth and development of...
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Fall 2015
Vertebrate eye development is a dynamic process that couples morphogenesis, migration of extraocular periocular mesenchyme (POM) cells to the eye, and retinal patterning along the nasotemporal and dorsoventral (DV) axes. Aberrant patterning during ocular development often results in defects...
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Fall 2009
Aroonassala Patten, Shunmoogum
Glutamate AMPA receptors (AMPARs) are major excitatory receptors in the vertebrate CNS. In many biological systems there are changes in the properties of AMPARs during development that are essential for providing an increase in efficiency of information transfer between neurons and a refinement...