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Skip to Search Results- 14Young, T. Kue
- 5Willows, Noreen D.
- 4Hegele, Robert A.
- 4Prado, Carla M.
- 3Fliegel, Larry
- 3Proctor, Spencer D.
- 53Graduate and Postdoctoral Studies (GPS), Faculty of
- 53Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 17Agricultural, Food and Nutritional Science, Department of
- 17Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 16School of Public Health
- 16School of Public Health/Journal Articles (Public Health)
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Rho-Kinase-Mediated Diphosphorylation of Myosin Regulatory Light Chain is a Unique Biochemical Mechanism in Human Uterine Myocytes
DownloadFall 2011
Rationale: Smooth muscle (SM) contraction results from activation of the cellular contractile machinery by phosphorylation of myosin regulatory light chain (RLC) at S19 (pRLC) by RLC kinase (MLCK). Subsequent phosphorylation at T18 yields diphosphorylated-RLC (ppRLC), which has been shown to...
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2009
Lix, Lisa M., Bruce, Sharon, Sarkar, Joykrishna, Young, T. Kue
"Background: In Canada, the prevalence of behavioural risk factors and chronic conditions differs for Aboriginal and non-Aboriginal populations, but little research has examined changes over time. This study compares several major risk factors and chronic conditions in Aboriginal and...
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Fall 2014
Cardiac Fatty acids β-oxidation (FAO) markedly increases during maturation and become the major source of energy for the adult heart. However, excessive rates of FAO can compromise cardiac function in obesity, diabetes, and heart failure. Lysine acetylation has recently been identified as a...
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2005
van Houten, B., Patel, M., Chan, C. B., Orrenius, S. , Fariss, M. W.
Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of numerous common diseases. The critical mitochondrial events responsible for oxidative stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. Several oxidative events...
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2011-07-01
Ng, Carmina, Corey, Paul N., Young, T. Kue
"Objectives: Large disparities exist between Aboriginal and non-Aboriginal Canadians in both obesity and socio-economic status (SES). The purpose of this paper was to assess associations between obesity and three indicators of SES–employment, education and income–in conjunction with demographic...
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2012
Birch, Daniel W., Gill, Richdeep S., Karmali, Shahzeer, Whitlock, Kevin
Obesity has become a major issue for healthcare providers as its prevalence continues to increase throughout the world. The literature suggests that increased body mass index (BMI) is associated with the development of certain cancers such as colorectal cancer (CRC). Consequently, CRC surgeons...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...