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Fall 2012
ATP actions on central inspiratory networks are determined by a three-part signaling system comprising: i) excitatory actions of ATP at P2 receptors (Rs) ii) ectonucleotidases that degrade ATP into adenosine (ADO), and iii) inhibitory actions of ADO at P1Rs. During hypoxia, an initial increase in...
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Spring 2010
Microglia, the resident immune cells of the central nervous system (CNS), become activated in response to danger signals given out by other cells when homeostasis has been disturbed. Microglial activation is a multifaceted phenomenon that includes numerous distinct phenotypes. The type of...
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Mechanisms underlying P2Y1 receptor-mediated excitation of the inspiratory network in vitro; and NPY-induced stress resilience in vitro and in vivo
DownloadSpring 2021
The present thesis will discuss the cellular and molecular mechanisms by which neurochemical systems modulate the activity of CNS networks underlying breathing and anxiety. The thesis is divided into two parts. The first part examines the mechanisms by which the neuromodulator/neurotransmitter...
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Postnatal development of the purinergic signaling system in the preBötzinger Complex; implications for the hypoxic ventilatory response
DownloadFall 2023
Low oxygen (hypoxia) evokes the biphasic hypoxic ventilatory response (HVR), in which carotid-body chemoreceptors trigger a rapid increase in ventilation (VE) followed by a centrally-mediated, secondary hypoxic depression of respiration (HRD) and metabolic rate (VO2) that involves adenosine. In...
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Spring 2016
The hypoxic ventilatory response comprises of an initial increase in ventilation, followed by a secondary depression that can be life threatening in premature infants. During hypoxia, ATP is released in the ventrolateral medulla, where it is suggested to attenuate the secondary hypoxic...
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Videos: ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri
Download2024-05-23
Videos to accompany the research article "ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri".