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The Regulatory Roles of Peptide IRW on angiotensin-converting enzyme 2 (ACE2) in High-Fat Diet-Induced Mice and Spontaneously Hypertensive Rats
DownloadFall 2023
Metabolic syndrome (MetS) refers to a cluster of various risk factors commonly associated with cardiovascular diseases (CVDs) and diabetes. Up-regulation of angiotensin-converting enzyme 2 (ACE2), a key member of the renin-angiotensin system (RAS), is generally protective against CVDs and...
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Spring 2016
Both ACE2 and apelin have been reported playing important roles in regulating cardiovascular structure and function. In this study, we used ACE2 or apelin gene knockout or knockdown mice to explore the roles of ACE2 or apelin in cardiovascular diseases. In particular, we created animal disease...
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Spring 2011
The traditional PI3K pathway relies on agonist mediated stimulation of PI3Kα through RTKs and PI3Kγ through GPCRs, which stimulate downstream enzymes such as Akt. This pathway has been found to be important in cardiomyocytes and cardiofibroblasts for regulating cardiac morphology and function....
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Fall 2012
Heart disease is a leading cause of morbidity and mortality in the world with a growing prevalence in a variety of manifestations. Many of the events that occur in the heart during the progression of disease have been explored to identify a causative mechanism to develop effective treatments and...
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Fall 2023
Thump Thump. Swoosh, swoosh. Kamlamunikk. Heart. Mi’kmaq teachings of heart are tied to concepts such as moontime, spirits, ancestors and blood knowledge. Being a Mi’kmaq woman from the west coast of Newfoundland with strong lifelong community connection I was aware that the understanding of...