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Skip to Search Results- 1Barakat, Khaled (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Dr. Ayman El-Kadi
- 1El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Haykowsky, Mark (Rehabilitation Medicine)
- 1Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
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Fall 2017
The voltage-gated KCNQ1/KCNE1 potassium ion channel plays a key role in maintaining the heart rhythm. An active channel generates the slow delayed rectifier (IKs) current in the heart. Both loss-of-function and gain-of-function mutations in KCNQ1 or KCNE1 are linked to many heart-related...
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Fall 2013
Breast cancer is the most common malignancy among females, and the second leading cause of cancer death among Canadian women. Despite improved survival, both short and long term detrimental effects have been observed with both novel and conventional anti-cancer therapies. In particular, the...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...