Search
Skip to Search Results
Filter
Author / Creator / Contributor
- 1Chan, Catherine B.
- 1Joseph, Jamie W.
- 1MacDonald, Patrick E.
- 1Sakellaropoulos, George
- 1Salapatek, Anne Marie F.
- 1Saleh, Monique C.
Subject / Keyword
Item type
Languages
Collections
Year
-
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic ß-cells enhances glucose-dependent insulin secretion
Download2002
Chan, Catherine B., Wang, Jianli, Sakellaropoulos, George, Tsushima, Robert G., Joseph, Jamie W., Smukler, Simon R., Sewing, Sabine, Saleh, Monique C., Wang, Jing, Salapatek, Anne Marie F., Wheeler, Michael B., MacDonald, Patrick E.
Voltage-dependent (Kv) outward K+ currents repolarize β-cell action potentials during a glucose stimulus to limit Ca2+ entry and insulin secretion. Dominant-negative “knockout” of Kv2 family channels enhances glucose-stimulated insulin secretion. Here we show that a putative Kv2.1 antagonist...
1 - 1 of 1