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Author / Creator / Contributor
- 1Baracos, Vickie
- 1Dieleman, Levinus
- 1Farhangfar, Arazm
- 1Gänzle, Michael G.
- 1Lin, Xiaoxi B.
- 1Sawyer, Michael B.
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
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Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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