Search

2012

Thomson, D., Chisholm, A., Hartling, L., Dryden, D. M.

Background: Overviews of systematic reviews compile data from multiple systematic reviews (SRs) and are a new method of evidence synthesis. Objectives: To describe the methodological approaches in overviews of interventions. Design: Descriptive study. Methods: We searched 4 databases from 2000 to...

2011

Seida, J., Vandermeer, B., Hartling, L., Dryden, D. M., Rowe, B. H., Bond, K.

Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...

2008

Clark, B., Hartling, L., Krebs Seida, J., Karkhaneh, M., Smith, V., Tjosvold, L., Ospina, M. B.

BACKGROUND: Much controversy exists regarding the clinical efficacy of behavioural and developmental interventions for improving the core symptoms of autism spectrum disorders (ASD). We conducted a systematic review to summarize the evidence on the effectiveness of behavioural and developmental...

2008

Offringa, M., Hartling, L., Craig, J. C., Klassen, T. P.

Children are often touted as being very important members of society because they represent our future. Optimizing their health outcomes has the potential for a huge impact on public health because children are at an early stage in the life trajectory. But it is often unclear how society...

2010

Tjosvold, L., Thomson, D., Vandermeer, B., Klassen, T. P., Cohen, E., Hartling, L.

Background The objective of this study was to describe randomized controlled trials (RCTs) and controlled clinical trials (CCTs) in child health published between 1948 and 2006, in terms of quantity, methodological quality, and publication and trial characteristics. We used the Trials Register...

2013

Scott, S. D., Moher, D., Klassen, T. P., Hartling, L., Hamm, M. P.

Introduction A research-practice gap exists between what is known about conducting methodologically rigorous randomized controlled trials (RCTs) and what is done. Evidence consistently shows that pediatric RCTs are susceptible to high risk of bias; therefore novel methods of influencing the...

2012

Dryden, D. M., Vandermeer, B., Seida, J., Hartling, L., Fernandes, R. M.

Background GRADE was developed to address shortcomings of tools to rate the quality of a body of evidence. While much has been published about GRADE, there are few empirical and systematic evaluations. Objective To assess GRADE for systematic reviews (SRs) in terms of inter-rater agreement and...

2014

Hartling, L., Vandermeer, B., Dryden, D. M., Fernandes, R. M., Hamm, M. P.

Objective: To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Design: Meta-epidemiological study. Data Sources: We identified systematic reviews containing a meta-analysis with 10–40 RCTs that were relevant to child health in...

2011

Bialy, L., Klassen, T. P., Hartling, L., Vandermeer, B., Johnson, D., Milne, A., Plint, A., Fernandes, R. M.

Objective To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years. Design Systematic review and meta-analysis. Data sources Medline, Embase, Central, Scopus, PubMed, LILACS,...

2010

Hartling, L., Johnson, D., Scott, S. D., Bishop, T., Klassen, T. P., Pandya, R.

BACKGROUND: Stories may be an effective tool to communicate with and influence patients because of their ability to engage the reader. The objective of this paper is to describe the development of a story-based intervention for delivery of health evidence to parents of children with croup for use...