Search

2012

Thomson, D., Chisholm, A., Hartling, L., Dryden, D. M.

Background: Overviews of systematic reviews compile data from multiple systematic reviews (SRs) and are a new method of evidence synthesis. Objectives: To describe the methodological approaches in overviews of interventions. Design: Descriptive study. Methods: We searched 4 databases from 2000 to...

2011

Seida, J., Vandermeer, B., Hartling, L., Dryden, D. M., Rowe, B. H., Bond, K.

Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...

2008

Offringa, M., Hartling, L., Craig, J. C., Klassen, T. P.

Children are often touted as being very important members of society because they represent our future. Optimizing their health outcomes has the potential for a huge impact on public health because children are at an early stage in the life trajectory. But it is often unclear how society...

2010

Tjosvold, L., Thomson, D., Vandermeer, B., Klassen, T. P., Cohen, E., Hartling, L.

Background The objective of this study was to describe randomized controlled trials (RCTs) and controlled clinical trials (CCTs) in child health published between 1948 and 2006, in terms of quantity, methodological quality, and publication and trial characteristics. We used the Trials Register...

2012

Dryden, D. M., Vandermeer, B., Seida, J., Hartling, L., Fernandes, R. M.

Background GRADE was developed to address shortcomings of tools to rate the quality of a body of evidence. While much has been published about GRADE, there are few empirical and systematic evaluations. Objective To assess GRADE for systematic reviews (SRs) in terms of inter-rater agreement and...

2004

Klassen, T. P., McConnell, D., Craig, W. R., Wiebe, N., Hartling, L., Bellemare, S., Russell, K.

Background Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries. We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy...

2014

Hartling, L., Vandermeer, B., Dryden, D. M., Fernandes, R. M., Hamm, M. P.

Objective: To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Design: Meta-epidemiological study. Data Sources: We identified systematic reviews containing a meta-analysis with 10–40 RCTs that were relevant to child health in...

2008

Russell, K., Liang, Y., O'Gorman, K., Klassen, T. P., Friesen, C., Dryden, D. M., Wild, T. C., Durec, T.

Background: Methamphetamine (MA) is a potent stimulant that is readily available. Its effects are similar to cocaine, but the drug has a profile associated with increased acute and chronic toxicities. The objective of this systematic review was to identify and synthesize literature on risk...

2011

Bialy, L., Klassen, T. P., Hartling, L., Vandermeer, B., Johnson, D., Milne, A., Plint, A., Fernandes, R. M.

Objective To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years. Design Systematic review and meta-analysis. Data sources Medline, Embase, Central, Scopus, PubMed, LILACS,...

2005

Cramer, K., Hartling, L., Wiebe, N., Klassen, T. P., Crumley, E. T.

Background Systematic reviewers seek to comprehensively search for relevant studies and summarize these to present the most valid estimate of intervention effectiveness. The more resources searched, the higher the yield, and thus time and costs required to conduct a systematic review. While there...