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Skip to Search Results- 2Chan, Catherine B.
- 1Fatehi-Hassanabad, Zahra
- 1Holloway, Graham P.
- 1MacDonald, Tara
- 1Perry, Christopher G.
- 1Wan, Zhongxiao
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Expression of PPARα modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice
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Fatehi-Hassanabad, Zahra, Chan, Catherine B.
Aims/hypothesis In uncoupling protein-2 (UCP2) knockout (KO) mice, protection of beta cells from fatty acid exposure is dependent upon transcriptional events mediated by peroxisome proliferator-activated receptor-α (PPARα). Methods PPARα expression was reduced in isolated islets from UCP2KO and...
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2012
Wan, Zhongxiao, MacDonald, Tara, Wright, David C., Holloway, Graham P., Chan, Catherine B., Perry, Christopher G.
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...