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2010
Clawson,M. L., Wang, Z., Stothard, P., McKay, S., Laegreid, W. W., Williams J. L., Murdoch, B. M., Settles, M., Moore, S. S., Prasad, A.
Background Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in...
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A high resolution radiation hybrid map of bovine chromosome 14 identifies scaffold rearrangement in the latest bovine assembly
Download2007
Stothard, P., Wang, Z., de Givry, S., Marques, E., Moore, S. S., Womack, J., Murdoch, B.
Background Radiation hybrid (RH) maps are considered to be a tool of choice for fine mapping closely linked loci, considering that the resolution of linkage maps is determined by the number of informative meiosis and recombination events which may require very large mapping populations....
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A Whole-Genome Scan to Map Quantitative Trait Loci for Conformation and Functional Traits in Canadian Holstein Bulls
Download2008
Grant, J. R., Moore, S. S., Xiu, Z., Murdoch, B. M., Kolbehdari, D., Stothard, P., Wang, Z., Prasad, A., Marques, E.
Genetic improvement of livestock populations can be achieved through detection and mapping of genetic markers linked to quantitative trait loci (QTL). With the completion of the bovine genome sequence assembly, single nucleotide polymorphism (SNP) assays spanning the whole bovine genome and...
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2011
Plastow, G., Durunna, O. N., Stothard, P., Mujibi, F. D. N., Moore, S. S., Wang, Z., Basarab, J. A., Nkrumah, D. J., Crews Jr, D. H., Mah, J.
The benefit of using genomic breeding values (GEBV) in predicting ADG, DMI, and residual feed intake for an admixed population was investigated. Phenotypic data consisting of individual daily feed intake measurements for 721 beef cattle steers tested over 5 yr was available for analysis. The...
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Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition
Download2004
Hansen, C., Murdoch, B., Guercio, S., Basarab, J. B., Moore, S. S., Meng, Y., Li, C., Nkrumah, J. D.
Leptin is a 16-kDa-hormone product of the obese gene synthesized and expressed predominantly by adipose tissues, which has been shown to play major roles in the regulation of body weight, feed intake, energy balance, fertility, and immune system functions. We report an investigation into the...
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Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Protein Complex, Subunit Alpha (COPA) Gene
Download2015
Sällman Almén, M., Liao, X., Stothard, P., Henegar, C., Van Doormaal, B., Rubin, C. -J., Andersson, L., Barsh, G. S., Ito, S., Plastow, G., Wakamatsu, K., Dorshorst, B.
Coat color in Holstein dairy cattle is primarily controlled by the melanocortin 1 receptor (MC1R) gene, a central determinant of black (eumelanin) vs. red/brown pheomelanin synthesis across animal species. The major MC1R alleles in Holsteins are Dominant Black (MC1RD) and Recessive Red (MC1Re). A...
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Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species
Download2013
Kommadath, A., Bao, H., Meng, Y., Plastow, G. S., Stothard, P., Sun, X., Arantes, A. S., Guan, L. L.
Background Understanding how species-specific microRNAs (miRNAs) contribute to species-specific phenotypes is a central topic in biology. This study aimed to elucidate the role of ruminant-specific miRNAs in shaping mRNA expression divergence between ruminant and non-ruminant species. ...
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Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding
Download2014
Plastow, G. S., Bearson, S. M. D., Arantes, A. S., Bao, H., Kommadath, A., Stothard, P., Guan, L. L., Tuggle, C. K.
Background Salmonella enterica serovar Typhimurium is a gram-negative bacterium that can colonise the gut of humans and several species of food producing farm animals to cause enteric or septicaemic salmonellosis. While many studies have looked into the host genetic response to Salmonella...
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Genetic parameters for production and feeding behaviour traits in crossbred steers fed a finishing diet at different ages
Download2013
Wang, Z., Nkrumah, D. J., Basarab, J. A., Durunna, O. N., Okine, E. K., Moore, S. S., Mujibi, F. D. N.
Because cattle can be raised postweaning under several feeding regimes, this study examined the consistency of phenotypic and genetic parameters of some production and feeding behaviour traits between two feeding periods that beef cattle received a finisher diet. Crossbred steers (n=851) were...
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2008
Kolbehdari, D., Stothard, P., Schnabel, R., Wang, Z., Marques, E., Taylor, J. F., Moore, S. S.
Background Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine...