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Skip to Search Results- 4Chan, Catherine B.
- 2Adisakwattana, Sirichai
- 2Joseph, Jamie W.
- 2Meeprom, Aramsri
- 2Saleh, Monique C.
- 2Sompong, Weerachat
- 2Advanced Glycation End Products
- 2Isoferulic Acid
- 1Bioenergetics
- 1Biogenesis
- 1DNA Damage
- 1Fructosamine
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2004
Zhang, Chen-Yu, Chan, Catherine B., Koshkin, Vasilij, Wheeler, Michael B., Lowell, Bradford B., Joseph, Jamie W., Saleh, Monique C., Sivitz, William I.
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...
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Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic ß-cells enhances glucose-dependent insulin secretion
Download2002
Chan, Catherine B., Wang, Jianli, Sakellaropoulos, George, Tsushima, Robert G., Joseph, Jamie W., Smukler, Simon R., Sewing, Sabine, Saleh, Monique C., Wang, Jing, Salapatek, Anne Marie F., Wheeler, Michael B., MacDonald, Patrick E.
Voltage-dependent (Kv) outward K+ currents repolarize β-cell action potentials during a glucose stimulus to limit Ca2+ entry and insulin secretion. Dominant-negative “knockout” of Kv2 family channels enhances glucose-stimulated insulin secretion. Here we show that a putative Kv2.1 antagonist...
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Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity
Download2015
Sompong, Weerachat, Suantawee, Tanyawan, Thilavech, Thavaree, Adisakwattana, Sirichai, Meeprom, Aramsri, Chan, Catherine B.
Background Isoferulic acid (IFA), a naturally occurring cinnamic acid derivative, is a main active ingredient of the rhizoma of Cimicifuga dahurica. It has been shown various pharmacological activities. The aim of the study was to investigate the effect of IFA against MG-induced protein glycation...
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Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro
Download2013
Meeprom, Aramsri, Adisakwattana, Sirichai, Sompong, Weerachat, Chan, Catherine B.
The inhibitory activity of isoferulic acid (IFA) on fructose- and glucose-mediated protein glycation and oxidation of bovine serum albumin (BSA) was investigated. Our data showed that IFA (1.25–5 mM) inhibited the formation of fluorescent advanced glycation end products (AGEs) and non-fluorescent...