Induction of apoptotic cell death by the dietary flavonol, quercetin, in MCF-7 and MDA-MB-231 breast adenocarcinoma cell lines

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  • Numerous studies have provided considerable evidence on quercetin's potential as a chemotherapeutic agent. Quercetin is a highly bioavailable dietary flavonoid that induces apoptosis in different cancer cell lines. Currently, the reported effects of this compound have been observed at concentration ranges of 40-250 μM. The purpose of this study is to investigate the apoptotic effects of quercetin in a dose- and time-dependent manner, at concentration ranges of 300-600 μM. At higher concentrations, there was no clear and observable relationship between the dose- and time-dependent treatment of quercetin and the
    number of viable MDA-MB-231 and MCF7 breast cancer cells as well as the percentage of apoptotic bodies. These unexpected results could be either attributed to the limitations of the experimental design, or could prove to be a novel finding. However, as with the latter, such inferences could not be drawn due to constraints in time and resources. For future experiments, a more comprehensive and elaborate experimental design is warranted.

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    Research Material
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    Attribution-NonCommercial 4.0 International