Oiling-out Crystallization on Solid Surfaces Controlled by Solvent Exchange

  • Author / Creator
    Choi, Howon
  • Oiling-out, also termed as liquid-liquid separation (LLPS), is a phenomenon well observed in cooling crystallization when the solution becomes cloudy due to the formation of a second liquid phase. One of the methods to control LLPS is solvent exchange where surface droplets are produce in bottom up approach. In this process, a good solvent for oil is displaced by a poor one, leading to oil nanodroplet nucleation and subsequent growth. The nanodroplets are immobilized on the surface therefore dynamics of the droplet formation and growth from LLPS can be monitored with time and quantitatively studied. We investigated oiling-out of a model component (Beta-alanine) in the mixture of isopropanol and water. The aqueous solution is displaced by isopropanol in a microchamber at controlled flow conditions. We followed the solute-rich droplet on the various substrates during the process of oiling-out. We expect that this study will give us new understanding on the dynamics of oiling-out phenomenon and the crystallization process. The knowledge may be valuable for controlling the oiling-out crystallization in the processes, separation, and purification of crystals for pharmaceutical use and other applications such as the use in functional surfaces and crystal shape engineering.

  • Subjects / Keywords
  • Graduation date
    Spring 2021
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.