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Magnetic resonance imaging based radiotherapy treatment planning: problems, solutions, and applications

  • Author / Creator
    Baldwin, Lesley
  • Despite their unmatched soft-tissue contrast, Magnetic Resonance (MR) images suffer from wide-ranging image distortions; this has raised questions about their suitability as an imaging modality upon which to base conformal radiation therapy treatment plans. This thesis addresses image distortion as it relates to the implementation of MR-based radiation therapy treatment planning (MR-RTP). A grid phantom was imaged at 3T to determine the 3D distortion field using in-house software. Using multiple images, both machine- and object-related sources of distortion were separated such that individual evaluation of distortion sources is possible. Over the imaging volume, nonlinearities in the gradients led to peak-to-peak image distortions of up to 11 mm. For in-vivo distortion quantification, the method was augmented with a modified gradient echo sequence which measures the phase evolution due to underlying field inhomogeneities. The amount of distortion measured using this technique is dependent upon both patient anatomy and sequence parameters, but was found to contribute 5.7 mm at maximum. The methods presented can be combined to provide comprehensive distortion rectification such that mean residual image distortion is reduced to well below the pixel resolution. Finally, distortion quantification and correction methods were applied to a clinical MR-RTP study of prostate patients. The dosimetric consequences of distortion correction were investigated by comparing 3D conformal and intensity modulated radiation therapy plans developed based on both uncorrected and corrected MRI data sets. Total image distortions and those directly affecting the prostate and organs at risk (OARs) were assessed and target doses, OAR doses, and dose volume histograms were compared. Maximum distortion (from all sources) was 7.8 mm. With the exception of two patients, changes in plan dosimetry were insignificant (<2% / <1Gy). Two patients who were poorly position suffered larger distortions in the target region which led to dosimetric differences of up to 4.2%.

  • Subjects / Keywords
  • Graduation date
    2010-11
  • Type of Item
    Thesis
  • Degree
    Doctor of Philosophy
  • DOI
    https://doi.org/10.7939/R3B91F
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Doctoral
  • Department
    • Department of Physics
  • Supervisor / co-supervisor and their department(s)
    • Fallone, Gino (Oncology)
  • Examining committee members and their departments
    • Ten Haken, Randall (Radiation Oncology, University of Michigan)
    • Robinson, Don (Oncology)
    • Rathee, Satyapal (Oncology)
    • Sloboda, Ron (Oncology)
    • Wilman, Alan (Biomedical Engineering)