Trends In and Barriers to the prenatal detection of major Congenital Heart Disease in Alberta

• Author / Creator

  Kaur, Amanpreet

• Introduction
  Congenital heart disease (CHD) affects approximately 8-13 per 1000 live births globally, and it is the leading cause of mortality and morbidity among neonates with birth defects. Most CHD can be diagnosed prenatally, which, particularly for more severe disease, is associated with improved outcomes. Despite the ability to diagnose almost all major CHD prenatally, current rates of detection, even in high-income countries, range between 30% to 60%. Whether recent modifications of obstetrical ultrasound (OB US) guidelines have led to improvements in the prenatal detection of certain forms of CHD in North America and internationally is unclear. As well, while the ease of detection of CHD subtypes at OB US is likely a significant predictor of prenatal diagnosis, other factors, including socioeconomic status (SES) and remoteness of residence (RoR) from tertiary care OB US screening and fetal echocardiography services, may also play a relevant role.
  Objectives
  1) To examine trends in prenatal diagnosis of major CHD in Alberta from 2008 through 2018
  2) To examine the impact of SES and geographic RoR on prenatal detection rates and timing in Alberta from 2008 to 2018
  Methods
  Using provincial databases, we retrospectively identified all fetuses and infants diagnosed between January 2008 to December 2018 with major CHD requiring surgical intervention within the first postnatal year.
  Objective 1: We evaluated individual lesions and categorized CHD subtypes based on the OB US fetal cardiac views required for detection: Group 1 - 4 chamber view (e.g. hypoplastic left heart syndrome, Ebstein’s anomaly, single ventricle), Group 2 - outflow tract view (e.g. tetralogy of Fallot, double-outlet right ventricle, truncus arteriosus), Group 3 - 3 vessel view/3 vessel tracheal view (3VV-3VT) or other non-standard cardiac views (e.g. coarctation, anomalous pulmonary veins), and 4 - isolated ventricular septal defects (VSDs) using any view.
  Objective 2: Using maternal residence postal code and geocoding, SES quintiles and geographic distance from fetal tertiary care, both continuous and categorical, were calculated. Outcome measures included the presence of a prenatal diagnosis and the gestational age at prenatal diagnosis when it occurred.
  Results
  From 2008-2018, 1405 patients (fetuses and infants) with major CHD were encountered pre and/or postnatally in Alberta, of whom 814 (58%) were diagnosed prenatally. Live births occurred in 1202 (84%), intrauterine fetal death (IUFD) in 47 (3.2%), elective termination of pregnancy (TOP) in 118 (8.3%) and missing data of 38 patient (4.5%).
  Objective 1: Over the study period, the proportion of prenatal diagnosis of major CHD significantly improved overall from 277/560 [49% 95% CI (confidence interval) 45, 54] in 2008-2012, 255/417 [61%, 95% CI 56, 65] in 2013-2015, to 282/428, [66%, 95% CI 61, 70] in 2016-2018 (p-value 100 km from the tertiary care center was associated with 16% greater risk of a postnatal diagnosis and 47% higher chance of a prenatal diagnosis after 22 weeks of gestation.
  Conclusions
  Prenatal detection rates of major CHD have significantly increased in Alberta from 2008-2018. With respect to OB US fetal cardiac views, prenatal detection of CHDs associated with four-chamber and outflow tract view abnormalities have increased. Although CHD associated with abnormalities of the 3VV-3VT and nonstandard views and isolated VSDs have also observed improved prenatal detection, rates for these subgroups remain suboptimal. While SES does not appear to impact rates of prenatal detection in our province, lower SES is associated with later gestational age when a prenatal diagnosis is made. In contrast, greater RoR from tertiary OB US and fetal echocardiography services in Alberta is significantly associated with both reduced rates of prenatal diagnosis and later prenatal diagnosis. Further work is needed to enhance prenatal screening through optimized OB US assessments, and to determine factors responsible for inequity in prenatal detection of CHD particularly for remote pregnancies in Alberta.

• Subjects / Keywords

  • Congenital Heart disease
  • Prenatal Detection Rate

• Graduation date

  Spring 2022

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/r3-h8jy-kx77

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.