Role of Glucagon-like Peptide-2 and Elemental Formula in Short Bowel Syndrome – Using Neonatal Piglets as an Animal Model

  • Author / Creator
    Hua, Zheng
  • Recovery from short bowel syndrome (SBS) requires intestinal adaptation, dependent on enteral nutrition (EN) and peptides, like glucagon-like peptide-2 (GLP-2). The purpose of this thesis was to investigate endogenous GLP-2 production and compare elemental versus polymeric formula in a neonatal animal model of SBS. Piglets were assigned mid-intestinal resection (JI); distal-intestinal resection (JC); or to a sham group. Postoperatively piglet’s commenced parenteral nutrition (PN), tapering as EN (elemental or polymeric) was increased. JI piglets had shorter PN duration (p<0.01), longer villi (p<0.01), deeper crypts (p<0.01) and higher plasma GLP-2 (p<0.001). Adaptation did not occur in JC piglets, while polymeric formula increased their duration of PN support (p<0.05) and plasma GLP-2 (p<0.05). This thesis shows that endogenous GLP-2 production is increased in association with adaptation in SBS piglets with ileum (JI). Polymeric formula increased endogenous GLP-2 in piglets without ileum, but did not benefit adaptation in neonatal SBS.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Medical Sciences-Paediatrics
  • Supervisor / co-supervisor and their department(s)
    • Wales, Paul W (Surgery, University of Toronto)
    • Turner, Justine M (Paediatrics)
  • Examining committee members and their departments
    • Ball, Ron (Agricultural, Life and Environmental Sciences)
    • Mager, Diana (Agricultural, Life and Environmental Sciences)