Exploring the Use of Nuclear Magnetic Resonance to Examine Spinal Cord Injury

• Author / Creator

  Hallihan, Daniel P

• Spinal cord injury is most commonly caused by physical
  trauma, and the resulting functional loss can vary considerably in
  both degree, extent and location.
  Understanding what spinal
  cord tissue is damaged and to what degree can be useful in both
  determining the appropriate treatment for individuals with spinal
  cord injury and for assessing novel methods of treatment. This
  thesis looks at the applications of nuclear magnetic resonance
  (NMR), to assess spinal cord injury, assess the effects of various
  treatments and assist in developing new treatments of spinal
  cord injury. The treatment of interest in this thesis is intra-spinal
  micro-stimulation (ISMS), a method of functional electrical
  stimulation (FES).
  Magnetic resonance imaging (MRI) provided
  grey/white matter contrast in images and ISMS micro-wire
  localization, water compartmentalization showed promise in
  determining
  myelination,
  and
  nuclear
  magnetic
  resonance
  spectroscopy (MRS) found several metabolites that varied due to
  spinal cord injury and could potentially be measured in-vivo.

• Subjects / Keywords

  • Magnetic Resonance Imaging
  • Spinal Cord Injury
  • Magnetic Resonance Spectroscopy

• Graduation date

  Spring 2013

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3JS3W

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.