Exploring the Use of Nuclear Magnetic Resonance to Examine Spinal Cord Injury

  • Author / Creator
    Hallihan, Daniel P
  • Spinal cord injury is most commonly caused by physical trauma, and the resulting functional loss can vary considerably in both degree, extent and location. Understanding what spinal cord tissue is damaged and to what degree can be useful in both determining the appropriate treatment for individuals with spinal cord injury and for assessing novel methods of treatment. This thesis looks at the applications of nuclear magnetic resonance (NMR), to assess spinal cord injury, assess the effects of various treatments and assist in developing new treatments of spinal cord injury. The treatment of interest in this thesis is intra-spinal micro-stimulation (ISMS), a method of functional electrical stimulation (FES). Magnetic resonance imaging (MRI) provided grey/white matter contrast in images and ISMS micro-wire localization, water compartmentalization showed promise in determining myelination, and nuclear magnetic resonance spectroscopy (MRS) found several metabolites that varied due to spinal cord injury and could potentially be measured in-vivo.

  • Subjects / Keywords
  • Graduation date
    Spring 2013
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.