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In vitro hematopoietic stem/progenitor cell proliferation and labeling

  • Author / Creator
    Xu, Peng
  • Hematopoietic stem/progenitor cells (HSPC) play main role in constituting the whole hematopoietic system. Furthermore, since recognized in 1960s, HSPC are utilized to protect patients from severe chemo and radio therapy. As time goes, they are also used to treat hematopoietic disorders such as leukemia. Bone marrow, peripheral blood and umbilical cord blood are now the three sources of HSPC. Umbilical cord blood seems optimal because it is easy to obtain, no risk to graft donor and low probability of infection transmission. However, low number of HSPCs in umbilical cord blood is the main limitation. My research focuses mainly on in-vitro proliferation of HSPCs. In addition, I also worked on labeling HSPC in-vitro for tracking these cells after transplantation. The experimental results indicated that HSPCs are effectively labeled and their proliferation rate is significantly enhanced in-vitro.

  • Subjects / Keywords
  • Graduation date
    2011-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3SH6F
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Biomedical Engineering
  • Supervisor / co-supervisor and their department(s)
    • Dr.Jie Chen (ECE&BME)
  • Examining committee members and their departments
    • Dr.Jame Xing (Laboratory medicine and pathology)
    • Dr. Jie Chen (ECE&BME)
    • Dr.Hasan Uludag (CME&BME)