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The Association of Exercise Blood Glucose Levels and Post-Exercise Hypoglycemia in Adults with Type 1 Diabetes
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- Author / Creator
- Hinz, Heather Ashley
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Guidelines suggest that people with type 1 diabetes (T1D) start exercise with moderately high blood glucose (8-10 mmol/L) (BG) to reduce the risk of hypoglycemia; however, those fearing hypoglycemia often start higher. This study aimed to determine the impact of afternoon aerobic exercise with a higher BG on post-exercise glycemia, as measured by continuous glucose monitoring (CGM). Eleven active T1D participants [8 female, 3 male, 30 ± 8 years, A1C 7.7 ± 0.8%, VO2peak 38.3 ± 7.8 ml/kg/min] completed two exercise sessions in random order: 1) with BG between 8.0-10.0 mmol/L (MOD) and 2) with BG between 12.0-14.0 mmol/L (HI). Participants were asked to keep meal timing/composition and insulin doses consistent between sessions. Participants cycled for 45 minutes at 60% VO2peak. Exercise intensity (respiratory exchange ratio, heart rate) was identical between sessions (p>0.05). CGM data [mean ± standard deviation] were assessed between 6:00pm-12:00am (6hr), and 12:00am-6:00am (nocturnal) after exercise. ANOVA revealed a main effect of condition for mean CGM glucose [MOD vs. HI, 6hr: 8.8 ±1.0 mmol/L vs 10.5 ± 2.6 mmol/L; nocturnal: 8.6 ± 1.4 mmol/L vs 9.8 ± 2.8 mmol/L; p=0.03], percent time in range [MOD vs HI, 6hr: 76 ± 16% vs 48 ± 28%; nocturnal: 72 ± 33% vs 58 ± 33%, p<0.01] and percent time in hyperglycemia (MOD vs HI, 6hr: 24 ± 16% vs 49 ± 29%; nocturnal: 27 ± 31% vs 42 ± 33%, p<0.01). We were unable to evaluate hypoglycemia protection due to a low number of events. Overall, higher exercise BG was associated with increased time in hyperglycemia and decreased time in range, and therefore, we recommend exercisers with T1D complete moderate aerobic exercise in the MOD range.
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- Graduation date
- Fall 2020
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- Type of Item
- Thesis
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- Degree
- Master of Science
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- License
- Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.