Changes in collateral blood flow and neuroprotective efficacy of transient aortic occlusion during acute ischemic stroke

• Author / Creator

  Ramakrishnan, Gomathi

• Ischemic stroke is the rapid loss of brain function due to occlusion of a cerebral blood vessel. It is a major cause of death and disability in the world; however, the approved thrombolytic treatments are ineffective in many patients and there is a need for better therapies for treating brain ischemia. One potential approach to enhance the cerebral perfusion to ischemic brain tissue is to augment collateral circulation. Collateral vasculature provides an alternate route for blood to reach ischemic tissue when the principal conduits are blocked. Collateral circulation can be augmented by transiently occluding the aorta to increase the cerebral blood flow. We investigated the efficacy of using transient aortic occlusion (TAO) in different models of ischemic stroke. Our findings suggest that TAO can augment collateral flow, though its efficacy varies in different models of stroke.

• Subjects / Keywords

  • Collateral blood flow
  • Transient aortic occlusion
  • Ischemic stroke

• Graduation date

  Spring 2014

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R37D52

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.