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Changes in collateral blood flow and neuroprotective efficacy of transient aortic occlusion during acute ischemic stroke

  • Author / Creator
    Ramakrishnan, Gomathi
  • Ischemic stroke is the rapid loss of brain function due to occlusion of a cerebral blood vessel. It is a major cause of death and disability in the world; however, the approved thrombolytic treatments are ineffective in many patients and there is a need for better therapies for treating brain ischemia. One potential approach to enhance the cerebral perfusion to ischemic brain tissue is to augment collateral circulation. Collateral vasculature provides an alternate route for blood to reach ischemic tissue when the principal conduits are blocked. Collateral circulation can be augmented by transiently occluding the aorta to increase the cerebral blood flow. We investigated the efficacy of using transient aortic occlusion (TAO) in different models of ischemic stroke. Our findings suggest that TAO can augment collateral flow, though its efficacy varies in different models of stroke.

  • Subjects / Keywords
  • Graduation date
    2014-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R37D52
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Centre for Neuroscience
  • Supervisor / co-supervisor and their department(s)
    • Todd,Kathryn (Psychiatry)
    • Winship, Ian R (Psychiatry)
  • Examining committee members and their departments
    • Colbourne,Fred (Psychology)
    • Shuaib,Ashfaq (Medicine)
    • Smith, Peter (Pharmacology)
    • Winship, Ian R (Psychiatry)
    • Todd,Kathryn (Psychiatry)