Decision Making Under Risk in Patients with HIV

  • Author / Creator
    Gilliam, Sara E
  • Individuals with human immunodeficiency virus (HIV) develop neurocognitive impairments, more frequently as the systemic disease progresses to AIDS. Among HIV-infected persons receiving antiretroviral therapy, executive dysfunctions are very commonly impaired. The present study examined HIV-infected patients’ propensity for risky decision making using the Game of Dice Task (GDT), known to covary with executive dysfunctions. Although other tasks and types of decision making have been reported to be impaired in HIV patients, previous study cohorts were complicated by concurrent substance abuse and other comorbidities. Here we used a relatively comorbidity-free population. HIV-infected patients (N=20) were impaired in the GDT, compared to matched healthy controls (N=20). The HIV-infected group also showed an erratic decision strategy across the task. GDT performance was related to measures of executive functioning. Erratic GDT choices were related to current CD4+ T-cell levels. This study provides the first evidence for impaired risky decision making in an HIV-infected population.

  • Subjects / Keywords
  • Graduation date
    Fall 2013
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
  • Supervisor / co-supervisor and their department(s)
  • Examining committee members and their departments
    • Power, Chris (Medicine, Medical Microbiology & Immunology)
    • Dixon, Roger (Psychology
    • Purdon, Scot (Psychiatry)