Statistical evaluation of tablet coating processes: influence of pan design and solvent type

• Author(s) / Creator(s)

  • Araci Bou-Chacra, N.
  • Löbenberg, R.
  • Pereira de Melo Jr., V.

• Partially and fully perforated pan coaters are among the most relevant types of equipment currently used in the process of coating tablets. The goal of this study was to assess the performance differences among these types of equipment employing a factorial design. This statistical approach allowed the simultaneous study of the process variables and verification of interactions among them. The study included partially-perforated and fully-perforated pan coaters, aqueous and organic solvents, as well as hypromellose-based immediate-release coating. The dependent variables were process time, energy consumption, mean weight of tablets and process yield. For the tests, placebo tablets with a mean weight of 250 mg were produced, divided into eight lots of two kilograms each and coated in duplicate, using both partially perforated pan and fully perforated pan coaters. The results showed a significant difference between the type of equipment used (partially and fully perforated pan coaters) with regard to process time and energy consumption, whereas no significant difference was identified for mean weight of the coated tablets and process yield.

• Date created

  2010

• Subjects / Keywords

  • Tablets/coating process
  • Partially perforated pan coater
  • Fully perforated pan coater

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/R3057CZ86

• License

  Attribution-NonCommercial 3.0 International