Effects of Dose and Parenteral Lipid Composition on Liver Function in Neonatal Piglets on Total Parenteral Nutrition

  • Author / Creator
    Josephson, Jessica K
  • Both parenteral lipid dose and fatty acid (FA) composition have been proposed as risk factors for neonatal intestinal failure associated liver disease (IFALD). This research compared conventional lipid (Intralipid®, n-6FA), dosed both high (10 g/kg/d) and low (5 g/kg/d), to fish oil (Omegaven®, n-3FA), dosed low (5 g/kg/d), in neonatal piglets at risk of IFALD. Piglets were given iso-nitrogenous TPN for 14 days and compared to sow fed controls. Outcome measures included bile flow, total body and brain weight. Bile flow was increased with fish-oil treatment and lowered with high dose Intralipid® (p < 0.05) while not different between low dose Intralipid® and controls. All TPN groups weighed less than controls (p < 0.05). Both low dose treatments were associated with reduced brain weight compared to the other groups (p < 0.05). These findings suggest that while low dose lipid treatments reduce the risk of developing IFALD, growth in neonates may be compromised.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Medical Sciences-Paediatrics
  • Supervisor / co-supervisor and their department(s)
    • Ball, Ronald (Agriculture, Life and Environmental Sciences)
    • Turner, Justine (Medical Sciences - Paediatrics)
  • Examining committee members and their departments
    • Field, Catherine (Agriculture, Life and Environmental Sciences)
    • Keelan, Monika (Laboratory Medicine and Pathology
    • Wales, Paul (Medical Sciences - Paediatrics)