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Development of a Sirolimus-eluting Mesh to Reduce Intra-Abdominal Adhesions

  • Author / Creator
    Maciver, Allison H
  • Postoperative intra-abdominal adhesions are a significant clinical problem. This project addresses the potential novel role for a sirolimus-eluting hydrogel in the setting of postoperative adhesions caused by polypropylene hernia repair mesh. We review recent literature on adhesion pathogenesis, and examine the progress in development of anti-adhesion agents and strategies. We hypothesize an antiproliferative and antifibrotic agent such as sirolimus may minimize or prevent the process at critical steps in the pathway. A mouse model was developed using a 1x1 cm2 polypropylene mesh implanted into the peritoneal cavity. This study revealed that the addition of an agarose hydrogel to the adhesiogenic mesh significantly reduced adhesion incidence, severity and tenacity, and adding sirolimus to the hydrogel further significantly reduced adhesion surface area. Sirolimus has been used in many novel clinical settings for its antifibrotic properties; this work supports its consideration with agarose hydrogel as a prophylactic against postoperative intra-abdominal adhesions.

  • Subjects / Keywords
  • Graduation date
    2012-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3FG8R
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Surgery
  • Specialization
    • Experimental Surgery
  • Supervisor / co-supervisor and their department(s)
    • Dr. A.M.J. Shapiro, Department of Surgery
  • Examining committee members and their departments
    • Dr. T.A. Churchill, Department of Surgery
    • Dr. D.L. Bigam, Department of Surgery
    • Dr. C.W. Teshima, Department of Medicine