Glucose Responsive Microgel Modified Quartz Crystal Microbalances as a Glucose Sensor

• Author / Creator

  Cho, Chung Yeon

• The Serpe group has shown that optical devices can be fabricated by layering poly (N-isopropylacrylamide) (pNIPAm) microgels onto a gold-coated glass substrate and then depositing another gold layer on top. These devices, called etalons, exhibit optical properties that depend on many characteristics, primarily temperature. Temperature is the most basic property of pNIPAm-based microgels, as it changes their solvation state. In this study, we modified pNIPAm-based microgels with 3-aminophenylboronic acid (APBA), which renders them responsive to glucose; i.e., they change size in a glucose-dependent fashion. By modifying the Au surface of a quartz crystal microbalance (QCM) with etalons composed of these microgels, we can make QCM-based devices that shift frequency as a function of glucose concentration in buffer solution. Again, this is a result of the microgels’ changing solvation state in response to glucose. It was determined that glucose-responsive pNIPAm microgel-based QCM can be used as a glucose sensor. This dissertation will detail the work done on these systems.

• Subjects / Keywords

  • GlucoseThe Serpe group has shown that optical devices can be fabricated by layering poly (N-isopropylacrylamide) (pNIPAm) microgels onto a gold-coated glass substrate and then depositing another gold layer on top. These devices
  • called etalons
  • exhibit optical properties that depend on many characteristics
  • primarily temperature. Temperature is the most basic property of pNIPAm-based microgels
  • as it changes their solvation state. In this study
  • we modified pNIPAm-based microgels with 3-aminophenylboronic acid (APBA)
  • which renders them responsive to glucose; i.e.
  • they change size in a glucose-dependent fashion. By modifying the Au surface of a quartz crystal microbalance (QCM) with etalons composed of these microgels
  • we can make QCM-based devices that shift frequency as a function of glucose concentration in buffer solution. Again
  • this is a result of the microgels’ changing solvation state in response to glucose. It was determined that glucose-responsive pNIPAm microgel-based QCM can be used as a glucose sensor. This dissertation will detail the work done on these systems
  • Sensor
  • Quartz Crystal Microbalance (QCM)
  • Poly (N-isopropylacrylamide) microgel

• Graduation date

  Spring 2016

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3FN1147D

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.