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Permanent link (DOI): https://doi.org/10.7939/R39882Z4R

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Cognitive Impairment following Transient Ischemic Attack and Minor Stroke Open Access

Descriptions

Other title
Subject/Keyword
cognitive impairment
minor stroke
transient ischemic attack
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Sivakumar, Leka
Supervisor and department
Butcher, Ken (Neurology)
Examining committee member and department
Camicioli, Richard (Neurology)
Beaulieau, Christian (Biomedical Engineering)
Jeerakathil, Thomas (Neurology)
Department
Centre for Neuroscience
Specialization

Date accepted
2013-09-26T14:15:12Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods: TIA/minor stroke patients (NIH Stroke Scale ≤ 3) underwent Montreal Cognitive Assessment, Mini-Mental Status Examination and MRI at baseline, days 7 and 30. Results: One hundred patients were included. MoCA detected cognitive impairment in 54% of patients at baseline. Recall deficits resolved, while deficits in language were persistent. WMH volumes were inversely predictive of MoCA scores after 30 days (β=-0.519, p<0.0001). Patients with persisting deficits were more likely to have frontal cortical lesions (86%, p=0.038) and higher WMH volumes (9.56mL, p=0.04). Conclusions: TIA/minor stroke patients have evidence of temporary acute cognitive impairment. Deficits are correlated with chronic WMH load. Temporary cognitive deficits should be considered in the management of TIA/minor stroke.
Language
English
DOI
doi:10.7939/R39882Z4R
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File format: pdf (Portable Document Format)
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File size: 6285315
Last modified: 2015:10:12 19:02:27-06:00
Filename: Sivakumar_Leka_Fall2013.pdf
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Status message: File header gives version as 1.4, but catalog dictionary gives version as 1.3
File title: Title Page_Sep18
File author: Leka Sivakumar
Page count: 131
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