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Permanent link (DOI): https://doi.org/10.7939/R32H45

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Effects of Dose and Parenteral Lipid Composition on Liver Function in Neonatal Piglets on Total Parenteral Nutrition Open Access

Descriptions

Other title
Subject/Keyword
Omega 3
Piglets
Parenteral Nutrition
Dose restriction
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Josephson, Jessica K
Supervisor and department
Turner, Justine (Medical Sciences - Paediatrics)
Ball, Ronald (Agriculture, Life and Environmental Sciences)
Examining committee member and department
Wales, Paul (Medical Sciences - Paediatrics)
Keelan, Monika (Laboratory Medicine and Pathology
Field, Catherine (Agriculture, Life and Environmental Sciences)
Department
Medical Sciences-Paediatrics
Specialization

Date accepted
2014-03-27T10:11:06Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
Both parenteral lipid dose and fatty acid (FA) composition have been proposed as risk factors for neonatal intestinal failure associated liver disease (IFALD). This research compared conventional lipid (Intralipid®, n-6FA), dosed both high (10 g/kg/d) and low (5 g/kg/d), to fish oil (Omegaven®, n-3FA), dosed low (5 g/kg/d), in neonatal piglets at risk of IFALD. Piglets were given iso-nitrogenous TPN for 14 days and compared to sow fed controls. Outcome measures included bile flow, total body and brain weight. Bile flow was increased with fish-oil treatment and lowered with high dose Intralipid® (p < 0.05) while not different between low dose Intralipid® and controls. All TPN groups weighed less than controls (p < 0.05). Both low dose treatments were associated with reduced brain weight compared to the other groups (p < 0.05). These findings suggest that while low dose lipid treatments reduce the risk of developing IFALD, growth in neonates may be compromised.
Language
English
DOI
doi:10.7939/R32H45
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: JK Josephson Thesis File.pdf
Page count: 69
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