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Effects of Dose and Parenteral Lipid Composition on Liver Function in Neonatal Piglets on Total Parenteral Nutrition Open Access


Other title
Omega 3
Parenteral Nutrition
Dose restriction
Type of item
Degree grantor
University of Alberta
Author or creator
Josephson, Jessica K
Supervisor and department
Turner, Justine (Medical Sciences - Paediatrics)
Ball, Ronald (Agriculture, Life and Environmental Sciences)
Examining committee member and department
Wales, Paul (Medical Sciences - Paediatrics)
Keelan, Monika (Laboratory Medicine and Pathology
Field, Catherine (Agriculture, Life and Environmental Sciences)
Medical Sciences-Paediatrics

Date accepted
Graduation date
Master of Science
Degree level
Both parenteral lipid dose and fatty acid (FA) composition have been proposed as risk factors for neonatal intestinal failure associated liver disease (IFALD). This research compared conventional lipid (Intralipid®, n-6FA), dosed both high (10 g/kg/d) and low (5 g/kg/d), to fish oil (Omegaven®, n-3FA), dosed low (5 g/kg/d), in neonatal piglets at risk of IFALD. Piglets were given iso-nitrogenous TPN for 14 days and compared to sow fed controls. Outcome measures included bile flow, total body and brain weight. Bile flow was increased with fish-oil treatment and lowered with high dose Intralipid® (p < 0.05) while not different between low dose Intralipid® and controls. All TPN groups weighed less than controls (p < 0.05). Both low dose treatments were associated with reduced brain weight compared to the other groups (p < 0.05). These findings suggest that while low dose lipid treatments reduce the risk of developing IFALD, growth in neonates may be compromised.
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