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Permanent link (DOI): https://doi.org/10.7939/R3DQ63

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Novel Models and Mechanisms in the Neurobiology of Anxiety Open Access

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Other title
Subject/Keyword
anxiety, hippocampus, amgydala, septum, neurophysiology, theta, behaviour, models, elevated plus maze, shock probe burying test
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Yeung, Michelle
Supervisor and department
Treit, Dallas (Psychology, Neuroscience)
Examining committee member and department
Sturdy, Christopher (Psychology, Neuroscience)
Winship, Ian (Psychiatry, Neuroscience)
Dickson, Clayton (Psychology, Neuroscience, Physiology)
Department
Department of Physics
Specialization

Date accepted
2011-08-28T13:18:03Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
Chapter 1 will provide a brief introduction to the neurobiology of anxiety, with an emphasis on three issues that have guided the current research. First, behavioral models of anxiety that have been useful in understanding its biological bases will be described. Second, the roles of the septum, hippocampus and amygdala in anxiety will be briefly summarized. Third, the antianxiety (anxiolytic) potential of a number of novel compounds will be described, as well as their effects in animal models of anxiety and in human anxiety. Chapter 2 describes four studies of the anxiolytic effects of the cyclic polypeptide somatostatin in two, extensively validated rat models of anxiolytic drug action: the elevated plus-maze and the shock-probe burying test. In particular, two isoforms of somatostatin (SST 14 and SST28) were microinfused into the central amygdala, the lateral septum, and the striatum (Yeung et al., 2011), with anxiolytic-like effects found in the first two structures but not the last, thus demonstrating the site-specificity of the results. In chapter 3, I conduct a critical test of Neil McNaughton’s hippocampal theta model of anxiolytic drug action. McNaughton and colleagues have repeatedly demonstrated that clinically proven anxiolytic drugs, regardless of their individual mechanisms of action, reliably suppress brain-stem evoked hippocampal theta. Such demonstrations, however, offer only weak evidence of the validity of any particular model of anxiolytic drug action, be it behavioral or neurophysiological. Phenytoin, a well-known antiepileptic drug with no known anxiolytic potential, was used to test the predictive validity of the theta suppression model. Chapter 4 summarizes the major results of these studies and their implications for current neuropharmacology theories of anxiety.
Language
English
DOI
doi:10.7939/R3DQ63
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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