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Role of Glucagon-like Peptide-2 and Elemental Formula in Short Bowel Syndrome – Using Neonatal Piglets as an Animal Model Open Access


Other title
elemental formula
glucagon-like peptide-2
animal model
short bowel syndrome
Type of item
Degree grantor
University of Alberta
Author or creator
Hua, Zheng
Supervisor and department
Turner, Justine M (Paediatrics)
Wales, Paul W (Surgery, University of Toronto)
Examining committee member and department
Mager, Diana (Agricultural, Life and Environmental Sciences)
Ball, Ron (Agricultural, Life and Environmental Sciences)
Medical Sciences-Paediatrics

Date accepted
Graduation date
Master of Science
Degree level
Recovery from short bowel syndrome (SBS) requires intestinal adaptation, dependent on enteral nutrition (EN) and peptides, like glucagon-like peptide-2 (GLP-2). The purpose of this thesis was to investigate endogenous GLP-2 production and compare elemental versus polymeric formula in a neonatal animal model of SBS. Piglets were assigned mid-intestinal resection (JI); distal-intestinal resection (JC); or to a sham group. Postoperatively piglet’s commenced parenteral nutrition (PN), tapering as EN (elemental or polymeric) was increased. JI piglets had shorter PN duration (p<0.01), longer villi (p<0.01), deeper crypts (p<0.01) and higher plasma GLP-2 (p<0.001). Adaptation did not occur in JC piglets, while polymeric formula increased their duration of PN support (p<0.05) and plasma GLP-2 (p<0.05). This thesis shows that endogenous GLP-2 production is increased in association with adaptation in SBS piglets with ileum (JI). Polymeric formula increased endogenous GLP-2 in piglets without ileum, but did not benefit adaptation in neonatal SBS.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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