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Comparison of tooth loss between intensity modulated and non-intensity modulated radiotherapy in head and neck cancer patients Open Access


Other title
tooth loss
head and neck
intensity modulated
Type of item
Degree grantor
University of Alberta
Author or creator
Beesley, Richelle Marie
Supervisor and department
Wolfaardt, Johan (Surgery)
Compton, Sharon (Dentistry)
Examining committee member and department
Parliament, Matthew (Radiation Oncology)
Rieger, Jana (Rehabilitation)
Seikaly, Hadi (Surgery)
Faculty of Medicine and Dentistry

Date accepted
Graduation date
Master of Science
Degree level
Advanced radiotherapy (RT) systems (intensity modulated radiotherapy, IMRT) is widely used to treat head and neck cancer. A combination of radiation and chemotherapy potentially increases toxicity as well as dental complications. Tooth loss was retrospectively assessed using oral cavity, oropharyngeal and nasopharyngeal cancer patients. Clinical photographs were used to determine differences between non-intensity modulated RT and IMRT. Subject data were collected pre – post RT from 2000 – 2010. Due to the paucity in the data, only the first two years after RT could not be included in the final analysis. Additionally, risk factors related to tooth loss were explored between treatment groups. While the number of teeth lost in both groups was shown to be similar, statistically there were no between group differences up to two years after RT. Further investigations are necessary to increase the sample size and timeframe after RT treatment to determine the clinical implications of these dental changes.
License granted by Richelle Beesley ( on 2011-09-15T18:50:10Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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