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Treatment Variation and Its Association with Survival in Patients Diagnosed with Stage I-III Breast Cancers in Alberta 2002-2010: A Population-Based Study Open Access


Other title
outcomes of breast cancer treatment
health inequality
treatment variation
breast cancer treatment
Type of item
Degree grantor
University of Alberta
Author or creator
Gao, He
Supervisor and department
Dr. Marcy Winget (Public Health)
Dr. Yutaka Yasui (Public Health)
Examining committee member and department
Dr. Yutaka Yasui (Public Health)
Dr. Kelly Dabbs (Medicine)
Dr. Marcy Winget (Public Health)
Department of Public Health Sciences
Date accepted
Graduation date
Master of Science
Degree level
Standard treatments for patients with stage I-III breast cancers include 1) breast conserving surgery (BCS) plus adjuvant radiotherapy; 2) mastectomy; and 3) BCS alone (e.g. age > 70 in stage I for ER/PR+ status and received hormone therapy). Currently, there is a lack of information regarding frequency and variation in utilization of these treatments in Alberta and information regarding the survival outcomes achieved in the general population by treatment type and stage. In this study, we found that rural patients were less likely to receive BCS. Stage I-III patients who received BCS plus adjuvant radiotherapy had a lower hazard of overall death and stage II or III patients had a lower hazard of breast-cancer-specific death than those who received mastectomy; additionally, stage I and II patients who received BCS alone had a higher hazard of overall and breast-cancer-specific death. These suggested an inequity of care among Alberta breast cancer patients.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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