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The role of intracellular calcium stores in the myogenic response of rat middle cerebral arteries Open Access


Other title
Intracellular calcium stores
Cerebral arteries
Myogenic response
Type of item
Degree grantor
University of Alberta
Author or creator
Tam, Raymond C
Supervisor and department
Plane, Frances (Pharmacology)
Kerr, Paul (Grant MacEwan University)
Examining committee member and department
Tse, Amy (Pharmacology)
Hemmings, Denise (Obstetrics and Gynecology)
Seubert, John (Faculty of Pharmacy & Pharmaceutical Sciences)
Department of Pharmacology

Date accepted
Graduation date
Master of Science
Degree level
The myogenic response is the ability of resistance arteries to constrict in response to blood pressure increases. As a key autoregulatory mechanism, this ability limits fluctuations in blood flow even when large blood pressure changes occur. The aim of my research is to examine the role of intracellular calcium stores in the myogenic response of rat middle cerebral arteries. I have addressed this aim by using pharmacological approaches to test two hypotheses: 1. smooth muscle sarcoplasmic reticulum (SR) provides an internal calcium source for myogenic response 2. the endothelium can modulate myogenic tone, and disruption of the endothelial endoplasmic reticulum will disturb myogenic reactivity My data demonstrate that in rat middle cerebral arteries, disruption of the smooth muscle cell SR results in loss of myogenic response. Also, although the endothelium does not actively regulate the myogenic response, disruption of endothelial cell calcium regulation can lead to myogenic tone loss.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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