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Simultaneous Measurement of Blood Flow and Oxygen Consumption Immediately Post-Exercise with Magnetic Resonance Imaging Open Access


Other title
Exercise Physiology
Magnetic Resonance Imaging
Blood Flow
Oxygen Consumption
Type of item
Degree grantor
University of Alberta
Author or creator
Mathewson, Kory W.
Supervisor and department
Thompson, Dr. Richard B. (Biomedical Engineering)
Examining committee member and department
Haykowsky, Dr. Mark (Rehabilitation Medicine)
Pituskin, Dr. Edith (Oncology)
Wilman, Dr. Alan (Biomedical Engineering)
Department of Biomedical Engineering

Date accepted
Graduation date
Master of Science
Degree level
Invasively measuring blood flow and oxygen consumption during exercise has been used to help advance performance, stratify fitness levels and most importantly to aid in clinical diagnoses and track disease or recovery progression. There is currently no non-invasive method for measuring skeletal muscle oxygen consumption and its determinants during dynamic exercise, which is necessary to expose mechanisms of dysfunction along the oxygen cascade in health and disease. In this thesis, I propose a new imaging approach which interleaves complex-difference (CD) and susceptometry magnetic resonance imaging (MRI) pulse sequences for real-time imaging of venous blood flow (VBF) and venous oxygen saturation (SvO2), respectively, for the calculation of skeletal muscle oxygen consumption (VO2). The goal of the major study comprising this thesis was to determine the reproducibility of this novel approach during sub-maximal single-leg knee-extensor (SLKE) exercise. When combined with cardiac and vascular studies, these non-invasive methods provide a possibility to investigate the relative contributions of the mechanisms reducing exercise capacity in those at risk for or with heart failure.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
A version of Chapter 2 of this thesis has been submitted for publication for consideration to Magnetic Resonance in Medicine (MRM) as Mathewson KW, Haykowsky MJ, Thompson RB. Feasibility and Reproducibility of Measurement of Whole Muscle Blood Flow, Oxygen Extraction and VO 2 with Dynamic Exercise Using MRI. (submitted August 2014).

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