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Perfluorinated Acids in Human Serum as Determinants of Maternal Hypothyroxinemia Open Access


Other title
Perfluorinated acids, thyroid hormone
Type of item
Degree grantor
University of Alberta
Author or creator
Chan, Emily
Supervisor and department
Martin, Jonathan W (Public Health Sciences/Laboratory Medicine and Pathology)
Examining committee member and department
Bamforth, Fiona (Laboratory Medicine and Pathology)
Burstyn, Igor (Medicine)
Senthiselvan, A (School of Public Health)
Cherry, Nicola (Medicine)
School of Public Health

Date accepted
Graduation date
Master of Science
Degree level
Perfluorinated acids (PFAs) are widespread global and human blood organohalogen contaminants. These monomer decomposition products used in surface treatment products and in fluoropolymer manufacturing and fire fighting may disrupt maternal thyroid hormone homeostasis given that animal studies demonstrate an apparent hypothyroxinemic condition upon PFA exposure. Firstly, we developed a method for properly quantifying perfluorohexane sulfonate (PFHxS), a PFA suspected of overreporting in past literature. We then investigated whether perfluorooctanoate (PFOA), PFHxS and perfluorooctane sulfonate (PFOS) were determinants of maternal hypothyroxinemia in a pregnant women population from Edmonton using a case-control design. Free thyroxine (fT4) and thyroid stimulating hormone (TSH) were screened in 974 women collected during 15-20 weeks of pregnancy. Cases (n=96, hypothyroxinemic: normal TSH and fT4: lowest 10th percentile) and controls (n=175, fT4: 50th and 90th percentile) were matched based on age and physician. Conditional logistic regression indicated that these PFAs are not associated with maternal hypothyroxinemia.
License granted by Emily Chan ( on 2010-04-13T23:30:54Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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