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Assessing White Matter Cortical Organization using Diffusion Tensor Imaging Post-Facial Reanimation Surgery Open Access


Other title
white matter
diffusion tensor imaging (DTI)
moebius syndrome
bell's palsy
facial reanimation surgery
Type of item
Degree grantor
University of Alberta
Author or creator
Phangureh, Navneet K
Supervisor and department
Boliek, Dr. Carol (Speech Pathology and Audiology)
Examining committee member and department
Olson, Dr. Jaret (Surgery)
Wilkes, Dr. Gordon (Surgery)
Cummine, Dr. Jacqueline (Speech Pathology and Audiology)
Department of Speech Pathology and Audiology
Speech-Language Pathology
Date accepted
Graduation date
Master of Science
Degree level
The purpose of this study was to determine whether diffusion tensor imaging (DTI) could detect cortical differences between people post-facial reanimation surgery compared to matched controls. Five primary white matter tracts were analyzed for fractional anisotropy (FA) and mean diffusivity (MD) and compared between 4 patients with facial reanimation surgery (ages 11 to 47 years) and their matched controls. Findings were in the predicted direction of lower FA and higher MD in regions of the brain containing corticobulbar tract (CBT) in the facial reanimation group compared to matched controls. This finding indicated that neural tracts associated with facial movements may have less white matter fibre tract integrity in this group of patients who have undergone reanimation surgery secondary to facial paralysis. The use of DTI tractography analysis may be useful in understanding underlying neural mechanisms of change following facial reanimation surgery and ultimately serve to inform surgical and rehabilitation processes.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Phangureh_Navneet_Spring 2012
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