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Changes in collateral blood flow and neuroprotective efficacy of transient aortic occlusion during acute ischemic stroke Open Access


Other title
Ischemic stroke
Collateral blood flow
Transient aortic occlusion
Type of item
Degree grantor
University of Alberta
Author or creator
Ramakrishnan, Gomathi
Supervisor and department
Todd,Kathryn (Psychiatry)
Winship, Ian R (Psychiatry)
Examining committee member and department
Smith, Peter (Pharmacology)
Todd,Kathryn (Psychiatry)
Colbourne,Fred (Psychology)
Winship, Ian R (Psychiatry)
Shuaib,Ashfaq (Medicine)
Centre for Neuroscience

Date accepted
Graduation date
Master of Science
Degree level
Ischemic stroke is the rapid loss of brain function due to occlusion of a cerebral blood vessel. It is a major cause of death and disability in the world; however, the approved thrombolytic treatments are ineffective in many patients and there is a need for better therapies for treating brain ischemia. One potential approach to enhance the cerebral perfusion to ischemic brain tissue is to augment collateral circulation. Collateral vasculature provides an alternate route for blood to reach ischemic tissue when the principal conduits are blocked. Collateral circulation can be augmented by transiently occluding the aorta to increase the cerebral blood flow. We investigated the efficacy of using transient aortic occlusion (TAO) in different models of ischemic stroke. Our findings suggest that TAO can augment collateral flow, though its efficacy varies in different models of stroke.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Winship IR, Armitage GA, Ramakrishnan G, Dong B, Todd KG, Shuaib A. Augmenting collateral blood flow during ischemic stroke via transient aortic occlusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013Armitage GA. Dynamics of the collateral vascular system [dissertation]. Ann Arbor: University of Alberta (Canada); 2010.Ramakrishnan G, Armitage GA, Winship IR. Understanding and augmenting collateral blood flow during ischemic stroke. Acute Ischemic Stroke. 2012.

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